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Ceria-Zirconia Nanoparticles as an Enhanced Multi-Antioxidant for Sepsis Treatment

Cited 246 time in Web of Science Cited 255 time in Scopus
Authors

Soh, Min; Kang, Dong-Wan; Jeong, Han-Gil; Kim, Dokyoon; Kim, Do Yeon; Yang, Wookjin; Song, Changyeong; Baik, Seungmin; Choi, In-Young; Ki, Seul-Ki; Kwon, Hyek Jin; Kim, Taeho; Kim, Chi Kyung; Lee, Seung-Hoon; Hyeon, Taeghwan

Issue Date
2017-09
Publisher
John Wiley & Sons Ltd.
Citation
Angewandte Chemie - International Edition, Vol.56 No.38, pp.11399-11403
Abstract
The two oxidation states of ceria nanoparticles, Ce3+ and Ce4+, play a pivotal role in scavenging reactive oxygen species (ROS). In particular, Ce3+ is largely responsible for removing O-2(-) and COH that are associated with inflammatory response and cell death. The synthesis is reported of 2 nm ceria-zirconia nanoparticles (CZ NPs) that possess a higher Ce3+/Ce4+ ratio and faster conversion from Ce4+ to Ce3+ than those exhibited by ceria nanoparticles. The obtained Ce0.7Zr0.3O2 (7CZ) NPs greatly improve ROS scavenging performance, thus regulating inflammatory cells in a very low dose. Moreover, 7CZ NPs are demonstrated to be effective in reducing mortality and systemic inflammation in two representative sepsis models. These findings suggest that 7CZ NPs have the potential as a therapeutic nanomedicine for treating ROS-related inflammatory diseases.
ISSN
1433-7851
URI
https://hdl.handle.net/10371/165917
DOI
https://doi.org/10.1002/anie.201704904
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College of Engineering/Engineering Practice School (공과대학/대학원)Dept. of Chemical and Biological Engineering (화학생물공학부)Journal Papers (저널논문_화학생물공학부)
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