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Comparative genomics of clinical and environmental Vibrio mimicus
DC Field | Value | Language |
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dc.contributor.author | Hasan, Nur A. | - |
dc.contributor.author | Grim, Christopher J. | - |
dc.contributor.author | Haley, Bradd J. | - |
dc.contributor.author | Chun, Jongsik | - |
dc.contributor.author | Alam, Munirul | - |
dc.contributor.author | Taviani, Elisa | - |
dc.contributor.author | Hoq, Mozammel | - |
dc.contributor.author | Munk, A. Christine | - |
dc.contributor.author | Saunders, Elizabeth | - |
dc.contributor.author | Brettin, Thomas S. | - |
dc.contributor.author | Bruce, David C. | - |
dc.contributor.author | Challacombe, Jean F. | - |
dc.contributor.author | Detter, J. Chris | - |
dc.contributor.author | Han, Cliff S. | - |
dc.contributor.author | Xie, Gary | - |
dc.contributor.author | Nair, G. Balakrish | - |
dc.contributor.author | Huq, Anwar | - |
dc.contributor.author | Colwell, Rita R. | - |
dc.date.accessioned | 2020-04-27T13:31:16Z | - |
dc.date.available | 2020-04-27T13:31:16Z | - |
dc.date.created | 2020-03-20 | - |
dc.date.created | 2020-03-20 | - |
dc.date.issued | 2010-12 | - |
dc.identifier.citation | Proceedings of the National Academy of Sciences of the United States of America, Vol.107 No.49, pp.21134-21139 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.other | 92996 | - |
dc.identifier.uri | https://hdl.handle.net/10371/165932 | - |
dc.description.abstract | Whether Vibrio mimicus is a variant of Vibrio cholerae or a separate species has been the subject of taxonomic controversy. A genomic analysis was undertaken to resolve the issue. The genomes of V. mimicus MB451, a clinical isolate, and VM223, an environmental isolate, comprise ca. 4,347,971 and 4,313,453 bp and encode 3,802 and 3,290 ORFs, respectively. As in other vibrios, chromosome I (C-I) predominantly contains genes necessary for growth and viability, whereas chromosome II (C-II) bears genes for adaptation to environmental change. C-I harbors many virulence genes, including some not previously reported in V. mimicus, such as mannose-sensitive hemagglutinin (MSHA), and enterotoxigenic hemolysin (HlyA); C-II encodes a variant of Vibrio pathogenicity island 2 (VPI-2), and Vibrio seventh pandemic island II (VSP-II) cluster of genes. Extensive genomic rearrangement in C-II indicates it is a hot spot for evolution and genesis of speciation for the genus Vibrio. The number of virulence regions discovered in this study (VSP-II, MSHA, HlyA, type IV pilin, PilE, and integron integrase, IntI4) with no notable difference in potential virulence genes between clinical and environmental strains suggests these genes also may play a role in the environment and that pathogenic strains may arise in the environment. Significant genome synteny with prototypic pre-seventh pandemic strains of V. cholerae was observed, and the results of phylogenetic analysis support the hypothesis that, in the course of evolution, V. mimicus and V. cholerae diverged from a common ancestor with a prototypic sixth pandemic genomic backbone. | - |
dc.language | 영어 | - |
dc.publisher | National Academy of Sciences | - |
dc.title | Comparative genomics of clinical and environmental Vibrio mimicus | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 천종식 | - |
dc.identifier.doi | 10.1073/pnas.1013825107 | - |
dc.citation.journaltitle | Proceedings of the National Academy of Sciences of the United States of America | - |
dc.identifier.wosid | 000285050800053 | - |
dc.identifier.scopusid | 2-s2.0-78650463454 | - |
dc.citation.endpage | 21139 | - |
dc.citation.number | 49 | - |
dc.citation.startpage | 21134 | - |
dc.citation.volume | 107 | - |
dc.identifier.sci | 000285050800053 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Chun, Jongsik | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | MANNOSE-SENSITIVE HEMAGGLUTININ | - |
dc.subject.keywordPlus | ZONULA-OCCLUDENS TOXIN | - |
dc.subject.keywordPlus | CHOLERAE EL-TOR | - |
dc.subject.keywordPlus | FILAMENTOUS PHAGE | - |
dc.subject.keywordPlus | ESCHERICHIA-COLI | - |
dc.subject.keywordPlus | SUPER-INTEGRONS | - |
dc.subject.keywordPlus | CTX-PHI | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | SEQUENCE | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
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