Publications
Detailed Information
pH-Sensitive Nanoformulated Triptolide as a Targeted Therapeutic Strategy for Hepatocellular Carcinoma
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ling, Daishun | - |
dc.contributor.author | Xia, Hongping | - |
dc.contributor.author | Park, Wooram | - |
dc.contributor.author | Hackett, Michael J. | - |
dc.contributor.author | Song, Changyeong | - |
dc.contributor.author | Na, Kun | - |
dc.contributor.author | Hui, Kam Man | - |
dc.contributor.author | Hyeon, Taeghwan | - |
dc.date.accessioned | 2020-04-27T13:44:54Z | - |
dc.date.available | 2020-04-27T13:44:54Z | - |
dc.date.created | 2018-01-10 | - |
dc.date.created | 2018-01-10 | - |
dc.date.issued | 2014-08 | - |
dc.identifier.citation | ACS Nano, Vol.8 No.8, pp.8027-8039 | - |
dc.identifier.issn | 1936-0851 | - |
dc.identifier.other | 11799 | - |
dc.identifier.uri | https://hdl.handle.net/10371/166108 | - |
dc.description.abstract | Hepatocellular carcinoma (HCC) has one of the worst prognoses for survival as it is poorly responsive to both conventional chemotherapy and mechanism-directed therapy. This results from a lack of therapeutic concentration in the tumor tissue coupled with the highly toxic off-site effects exhibited by these compounds. Consequently, we believe the best packaging for holistic therapy for HCC will involve three components: a potent therapeutic a rationally designed drug delivery vehicle to enrich the target site concentration of the drug, and a surfaceligand that can enable a greater propensity to internalization by tumor cells compared to the parenchyma. We screened a library containing hundreds of compounds against a panel of HCC cells and found the natural product triptolide, to be more effective than sorafenib, doxorubicin, and daunorubicin, which are the current standards of therapy. However, the potential clinical application of triptolide is limited due to its poor solubility and high toxicity. Consequently, we synthesized tumor pH sensitive nanoformulated triptolide coated with folate for use in an HCC-subpopulation that overexpresses the folate receptor. Our results show triptolide itself can prevent disease progression, but at the cost of significant toxicity. Conversely, our pH-sensitive nanoformulated triptolide facilitates uptake into the tumor, and specifically | - |
dc.language | 영어 | - |
dc.publisher | American Chemical Society | - |
dc.title | pH-Sensitive Nanoformulated Triptolide as a Targeted Therapeutic Strategy for Hepatocellular Carcinoma | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 현택환 | - |
dc.identifier.doi | 10.1021/nn502074x | - |
dc.citation.journaltitle | ACS Nano | - |
dc.identifier.wosid | 000340992300048 | - |
dc.identifier.scopusid | 2-s2.0-84906708265 | - |
dc.citation.endpage | 8039 | - |
dc.citation.number | 8 | - |
dc.citation.startpage | 8027 | - |
dc.citation.volume | 8 | - |
dc.identifier.sci | 000340992300048 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Hyeon, Taeghwan | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | PHOTODYNAMIC THERAPY | - |
dc.subject.keywordPlus | POLYMERIC MICELLE | - |
dc.subject.keywordPlus | CANCER-CELLS | - |
dc.subject.keywordPlus | TUMOR PH | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | MICROENVIRONMENT | - |
dc.subject.keywordPlus | NANOMEDICINE | - |
dc.subject.keywordPlus | RECURRENCE | - |
dc.subject.keywordAuthor | hepatocellular carcinoma | - |
dc.subject.keywordAuthor | triptolide | - |
dc.subject.keywordAuthor | pH sensitive polymer | - |
dc.subject.keywordAuthor | targeted cancer therapy | - |
dc.subject.keywordAuthor | drug delivery | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.