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A general strategy for site-directed enzyme immobilization by using NiO nanoparticle decorated mesoporous silica

Cited 32 time in Web of Science Cited 34 time in Scopus
Authors

Ling, Daishun; Gao, Liqian; Wang, Jianpeng; Shokouhimehr, Mohammadreza; Liu, Jiahui; Yu, Yongsheng; Hackett, Michael J.; So, Pui-Kin; Zheng, Bo; Yao, Zhongping; Xia, Jiang; Hyeon, Taeghwan

Issue Date
2014-06
Publisher
John Wiley & Sons Ltd.
Citation
Chemistry - A European Journal, Vol.20 No.26, pp.7916-7921
Abstract
Mesoporous materials have recently gained much attention owing to their large surface area, narrow pore size distribution, and superior pore structure. These materials have been demonstrated as excellent solid supports for immobilization of a variety of proteins and enzymes for their potential applications as biocatalysts in the chemical and pharmaceutical industries. However, the lack of efficient and reproducible methods for immobilization has limited the activity and recyclability of these biocatalysts. Furthermore, the biocatalysts are usually not robust owing to their rapid denaturation in bulk solvents. To solve these problems, we designed a novel hybrid material system, mesoporous silica immobilized with NiO nanoparticles (SBA-NiO), wherein enzyme immobilization is directed to specific sites on the pore surface of the material. This yielded the biocatalytic species with higher activity than free enzyme in solution. These biocatalytic species are recyclable with minimal loss of activity after several cycles, demonstrating an advantage over free enzymes.
ISSN
0947-6539
URI
https://hdl.handle.net/10371/166134
DOI
https://doi.org/10.1002/chem.201403071
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  • College of Engineering
  • School of Chemical and Biological Engineering
Research Area Chemistry, Materials Science

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