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High-resolution three-photon biomedical imaging using doped ZnS nanocrystals
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yu, Jung Ho | - |
dc.contributor.author | Kwon, Seung-Hae | - |
dc.contributor.author | Petrasek, Zdenek | - |
dc.contributor.author | Park, Ok Kyu | - |
dc.contributor.author | Jun, Samuel Woojoo | - |
dc.contributor.author | Shin, Kwangsoo | - |
dc.contributor.author | Choi, Moonkee | - |
dc.contributor.author | Park, Yong Il | - |
dc.contributor.author | Park, Kyeongsoon | - |
dc.contributor.author | Na, Hyon Bin | - |
dc.contributor.author | Lee, Nohyun | - |
dc.contributor.author | Lee, Dong Won | - |
dc.contributor.author | Kim, Jeong Hyun | - |
dc.contributor.author | Schwille, Petra | - |
dc.contributor.author | Hyeon, Taeghwan | - |
dc.date.accessioned | 2020-04-27T13:49:07Z | - |
dc.date.available | 2020-04-27T13:49:07Z | - |
dc.date.created | 2020-03-17 | - |
dc.date.issued | 2013-04 | - |
dc.identifier.citation | Nature Materials, Vol.12 No.4, pp.359-366 | - |
dc.identifier.issn | 1476-1122 | - |
dc.identifier.other | 92728 | - |
dc.identifier.uri | https://hdl.handle.net/10371/166167 | - |
dc.description.abstract | Three-photon excitation is a process that occurs when three photons are simultaneously absorbed within a luminophore for photo-excitation through virtual states. Although the imaging application of this process was proposed decades ago, three-photon biomedical imaging has not been realized yet owing to its intrinsic low quantum efficiency. We herein report on high-resolution in vitro and in vivo imaging by combining three-photon excitation of ZnS nanocrystals and visible emission from Mn2+ dopants. The large three-photon cross-section of the nanocrystals enabled targeted cellular imaging under high spatial resolution, approaching the theoretical limit of three-photon excitation. Owing to the enhanced Stokes shift achieved through nanocrystal doping, the three-photon process was successfully applied to high-resolution in vivo tumour-targeted imaging. Furthermore, the biocompatibility of ZnS nanocrystals offers great potential for clinical applications of three-photon imaging. | - |
dc.language | 영어 | - |
dc.publisher | Nature Publishing Group | - |
dc.title | High-resolution three-photon biomedical imaging using doped ZnS nanocrystals | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 현택환 | - |
dc.identifier.doi | 10.1038/NMAT3565 | - |
dc.citation.journaltitle | Nature Materials | - |
dc.identifier.wosid | 000317164900026 | - |
dc.identifier.scopusid | 2-s2.0-84875408863 | - |
dc.citation.endpage | 366 | - |
dc.citation.number | 4 | - |
dc.citation.startpage | 359 | - |
dc.citation.volume | 12 | - |
dc.identifier.sci | 000317164900026 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Hyeon, Taeghwan | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | SEMICONDUCTOR QUANTUM DOTS | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | LIVE CELLS | - |
dc.subject.keywordPlus | BAND-EDGE | - |
dc.subject.keywordPlus | FLUORESCENCE | - |
dc.subject.keywordPlus | MICROSCOPY | - |
dc.subject.keywordPlus | EXCITATION | - |
dc.subject.keywordPlus | EMISSION | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | PHOTOLUMINESCENCE | - |
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