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High-resolution three-photon biomedical imaging using doped ZnS nanocrystals

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dc.contributor.authorYu, Jung Ho-
dc.contributor.authorKwon, Seung-Hae-
dc.contributor.authorPetrasek, Zdenek-
dc.contributor.authorPark, Ok Kyu-
dc.contributor.authorJun, Samuel Woojoo-
dc.contributor.authorShin, Kwangsoo-
dc.contributor.authorChoi, Moonkee-
dc.contributor.authorPark, Yong Il-
dc.contributor.authorPark, Kyeongsoon-
dc.contributor.authorNa, Hyon Bin-
dc.contributor.authorLee, Nohyun-
dc.contributor.authorLee, Dong Won-
dc.contributor.authorKim, Jeong Hyun-
dc.contributor.authorSchwille, Petra-
dc.contributor.authorHyeon, Taeghwan-
dc.date.accessioned2020-04-27T13:49:07Z-
dc.date.available2020-04-27T13:49:07Z-
dc.date.created2020-03-17-
dc.date.issued2013-04-
dc.identifier.citationNature Materials, Vol.12 No.4, pp.359-366-
dc.identifier.issn1476-1122-
dc.identifier.other92728-
dc.identifier.urihttps://hdl.handle.net/10371/166167-
dc.description.abstractThree-photon excitation is a process that occurs when three photons are simultaneously absorbed within a luminophore for photo-excitation through virtual states. Although the imaging application of this process was proposed decades ago, three-photon biomedical imaging has not been realized yet owing to its intrinsic low quantum efficiency. We herein report on high-resolution in vitro and in vivo imaging by combining three-photon excitation of ZnS nanocrystals and visible emission from Mn2+ dopants. The large three-photon cross-section of the nanocrystals enabled targeted cellular imaging under high spatial resolution, approaching the theoretical limit of three-photon excitation. Owing to the enhanced Stokes shift achieved through nanocrystal doping, the three-photon process was successfully applied to high-resolution in vivo tumour-targeted imaging. Furthermore, the biocompatibility of ZnS nanocrystals offers great potential for clinical applications of three-photon imaging.-
dc.language영어-
dc.publisherNature Publishing Group-
dc.titleHigh-resolution three-photon biomedical imaging using doped ZnS nanocrystals-
dc.typeArticle-
dc.contributor.AlternativeAuthor현택환-
dc.identifier.doi10.1038/NMAT3565-
dc.citation.journaltitleNature Materials-
dc.identifier.wosid000317164900026-
dc.identifier.scopusid2-s2.0-84875408863-
dc.citation.endpage366-
dc.citation.number4-
dc.citation.startpage359-
dc.citation.volume12-
dc.identifier.sci000317164900026-
dc.description.isOpenAccessN-
dc.contributor.affiliatedAuthorHyeon, Taeghwan-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.subject.keywordPlusSEMICONDUCTOR QUANTUM DOTS-
dc.subject.keywordPlusIN-VIVO-
dc.subject.keywordPlusLIVE CELLS-
dc.subject.keywordPlusBAND-EDGE-
dc.subject.keywordPlusFLUORESCENCE-
dc.subject.keywordPlusMICROSCOPY-
dc.subject.keywordPlusEXCITATION-
dc.subject.keywordPlusEMISSION-
dc.subject.keywordPlusNANOPARTICLES-
dc.subject.keywordPlusPHOTOLUMINESCENCE-
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