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Water-dispersible ferrimagnetic iron oxide nanocubes with extremely high r 2 relaxivity for highly sensitive in vivo MRI of tumors

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dc.contributor.authorLee, Nohyun-
dc.contributor.authorChoi, Yoonseok-
dc.contributor.authorLee, Youjin-
dc.contributor.authorPark, Mihyun-
dc.contributor.authorMoon, Woo Kyung-
dc.contributor.authorChoi, Seung Hong-
dc.contributor.authorHyeon, Taeghwan-
dc.date.accessioned2020-04-27T13:51:57Z-
dc.date.available2020-04-27T13:51:57Z-
dc.date.issued2012-06-
dc.identifier.citationNano Letters, Vol.12 No.6, pp.3127-3131-
dc.identifier.issn1530-6984-
dc.identifier.other92746-
dc.identifier.urihttps://hdl.handle.net/10371/166201-
dc.description.abstractThe theoretically predicted maximum r(2) relaxivity of iron oxide nanoparticles was achieved by optimizing the overall size of ferrimagnetic iron oxide nanocubes. Uniform-sized iron oxide nanocubes with an edge length of 22 nm, encapsulated with PEG-phospholipids (WFION), exhibited high colloidal stability in aqueous media. In addition, WFIONs are biocompatible and did not affect cell viability at concentrations up to 0.75 mg Fe/ml. Owing to the enhanced colloidal stability and the high r(2) relaxivity (761 mM(-1) s(-1)), it was possible to successfully perform in vivo MR imaging of tumors by intravenous injection of 22-nm-sized WFIONs, using a clinical 3-T MR scanner.-
dc.subjectNanoparticle-
dc.subjectnanomedicine-
dc.subjectiron oxide-
dc.subjectmagnetic resonance imaging contrast agent-
dc.subjectcolloidal stability-
dc.titleWater-dispersible ferrimagnetic iron oxide nanocubes with extremely high r 2 relaxivity for highly sensitive in vivo MRI of tumors-
dc.typeArticle-
dc.contributor.AlternativeAuthor최승홍-
dc.contributor.AlternativeAuthor문우경-
dc.contributor.AlternativeAuthor현택환-
dc.identifier.doi10.1021/nl3010308-
dc.citation.journaltitleNano Letters-
dc.identifier.scopusid2-s2.0-84862272360-
dc.citation.endpage3131-
dc.citation.number6-
dc.citation.startpage3127-
dc.citation.volume12-
dc.identifier.urlhttps://pubs.acs.org/doi/10.1021/nl3010308-
dc.identifier.rimsid92746-
dc.identifier.sci000305106400079-
dc.description.isOpenAccessN-
dc.contributor.affiliatedAuthorHyeon, Taeghwan-
Appears in Collections:
College of Engineering/Engineering Practice School (공과대학/대학원)Dept. of Chemical and Biological Engineering (화학생물공학부)Journal Papers (저널논문_화학생물공학부)
College of Engineering/Engineering Practice School (공과대학/대학원)Dept. of Chemical and Biological Engineering (화학생물공학부)Chemical Convergence for Energy and Environment (에너지환경 화학융합기술전공)Journal Papers (저널논문_에너지환경 화학융합기술전공)
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