액상 색전 물질의 접착성을 조절하기 위한 불소화 시아노 아크릴레이트 디자인

Abstract

Embolotherapy is a method of inserting a catheter into the body to block the vessel or necrosis the tissue by infusion of an embolic materials. Embolic materials are classified according to the location of the lesion of vessel or the disease. Cyanoacrylate, one of the liquid embolic materials, is used in clinic with tantalum powder or oil with radiopacity. In order to improve this, in the previous study, the cyanoacrylate which have radiopacity was designed and synthesized. This new cyanoacrylate monomer has a problem that polymerization of cyanoacrylate monomer is decreased when oil is added to reduce adhesiveness. To improve this, various fluorinated cyanoacrylates were designed and three monomer ( named F, CF, FF) were synthesized according to the fluorine content and carbon chain length of side group. The polymerization rate and adhesiveness of mixture of monomer and oil with ratio 1:0 to 1:3 were measured and compared Histoacryl® which already used in clinical purpose. As a result, it was confirmed that the polymerization rate was accelerated as fluorine content was increased. In addition, the polymerization rate of monomer FF ,the monomer with highest fluorine content among three monomers, was not as slow as the other monomer when oil is added. And at the same time, the adhesiveness was decreased with similar amount of other monomers. In conclusion, mixture of monomer FF and oil has fastest polymerization rate and similar adhesiveness with other monomers. Through it is expected to be used as a replaced cyanoacrylate in composition in previous study.