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Peripheral arterial endothelial dysfunction predicts future cardiovascular events in diabetic patients with albuminuria: a prospective cohort study
DC Field | Value | Language |
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dc.contributor.author | Koo, Bo Kyung | - |
dc.contributor.author | Chung, Woo-Young | - |
dc.contributor.author | Moon, Min Kyong | - |
dc.date.accessioned | 2020-07-15T05:14:33Z | - |
dc.date.available | 2020-07-15T14:15:26Z | - |
dc.date.issued | 2020-06-13 | - |
dc.identifier.citation | Cardiovascular Diabetology. 2020 Jun 13;19(1):82 | ko_KR |
dc.identifier.issn | 1475-2840 | - |
dc.identifier.uri | https://hdl.handle.net/10371/168591 | - |
dc.description.abstract | Background
Reactive hyperemia-peripheral arterial tonometry (RH-PAT) is a noninvasive and simple test for evaluating the endothelial function. There has been sparse evidence on the usefulness of the RH-PAT index (RHI) in predicting future cardiovascular diseases among diabetic patients. Methods Asymptomatic diabetic patients with albuminuria were selected; their medical history and laboratory findings were evaluated every 3 to 4months, respectively. The primary outcome was a composite of three-point major adverse cardiovascular events (3-point MACE): death from cardiovascular causes, acute coronary events, or nonfatal stroke. On the contrary, secondary outcomes included a composite of 3-point MACE, hospitalization for heart failure, or chronic kidney disease (CKD) progression. RHI was measured using the Endo-PAT2000 at the baseline. RHI < 1.67 was considered to indicate peripheral endothelial dysfunction (PED). Results In total, 149 subjects were included (mean age, 61.8 ± 9.2years; duration of diabetes was 12years). During the follow-up period (median, 49.7months), of the 149 subjects, primary outcomes were detected in 12 (1 [2.3%] and 11 [10.5%] of those without and with PED, respectively). The presence of PED in baseline measurements significantly increased both primary and secondary outcomes, following adjustment for age, sex, hypertension, glycated hemoglobin, low-density lipoprotein cholesterol, triglyceride, systolic blood pressure, baseline estimated glomerular filtration rate, overt proteinuria, duration of diabetes, premedical history of ischemic events, anti-platelet agents, and smoking history (hazard ratio [HR]: 10.95; 95% confidence interval CI 1.00–119.91 for the primary outcome; HR, 4.12; 95% CI 1.37–12.41 for secondary outcome). In addition, PED could predict secondary outcomes independent of the risk score according to the American College of Cardiology/American Heart Association (HR: 3.24; 95% CI 1.14–9.17). Conclusions PED can independently predict future cardiovascular events among diabetic patients with albuminuria. | ko_KR |
dc.description.sponsorship | This study was supported by Health Connect Research Fund (No. 16-2013-87). | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BMC | ko_KR |
dc.subject | Reactive hyperemia | - |
dc.subject | Endothelial function | - |
dc.subject | Type 2 diabetes | - |
dc.subject | Ischemic heart disease | - |
dc.subject | Nonfatal stroke | - |
dc.subject | Heart failure | - |
dc.subject | Chronic kidney disease | - |
dc.title | Peripheral arterial endothelial dysfunction predicts future cardiovascular events in diabetic patients with albuminuria: a prospective cohort study | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 구보경 | - |
dc.contributor.AlternativeAuthor | 정우영 | - |
dc.contributor.AlternativeAuthor | 문민경 | - |
dc.identifier.doi | 10.1186/s12933-020-01062-z | - |
dc.citation.journaltitle | Cardiovascular Diabetology | ko_KR |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s) | - |
dc.date.updated | 2020-06-16T09:34:29Z | - |
dc.citation.number | 1 | ko_KR |
dc.citation.startpage | 82 | ko_KR |
dc.citation.volume | 19 | ko_KR |
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