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Transcriptome profiling of pluripotent pig embryonic stem cells originating from uni- and biparental embryos
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, Kwang-Hwan | - |
dc.contributor.author | Lee, Dong-Kyung | - |
dc.contributor.author | Oh, Jong-Nam | - |
dc.contributor.author | Kim, Seung-Hun | - |
dc.contributor.author | Lee, Mingyun | - |
dc.contributor.author | Kim, Sung Woo | - |
dc.contributor.author | Lee, Chang-Kyu | - |
dc.date.accessioned | 2020-09-01T05:39:14Z | - |
dc.date.available | 2020-09-01T14:44:34Z | - |
dc.date.issued | 2020-03-11 | - |
dc.identifier.citation | BMC Research Notes. 2020 Mar 11;13(1):144 | ko_KR |
dc.identifier.issn | 1756-0500 | - |
dc.identifier.uri | https://hdl.handle.net/10371/168781 | - |
dc.description.abstract | Objectives
Pig pluripotent stem cells have tremendous potential because the pig is a valuable animal as both an agricultural resource and as a preclinical model of human therapy. To date, a lack of understanding of pig pluripotency has inhibited the derivation of embryonic stem cells (ESCs) and transgene-free induced pluripotent stem cells. Therefore, there has been no accessible or reliable transcriptome data for researching the genuine pig pluripotency network. Our previous study isolated authentic pig ESCs, which had teratoma-forming and direct differentiation ability, that were derived by activating the FGF2, ACTIVIN A, and WNT pathways. Here, we aimed to provide detailed information on transcriptome data of the newly derived pig ESCs and perform a comparative analysis with pig preimplantation embryo transcriptomes in a public database. Data description The transcriptome data of ESCs derived from in vitro fertilized and parthenogenetic embryos were generated by HiSeq2500. Then, differentially expressed genes (DEGs) from each sample were compared with fibroblasts, and gene expression profiling was carried out for comparative analysis. Our data, as the first transcriptome dataset for genuine pig pluripotent cells, could be a general reference for explaining the molecular mechanism of species-specific pluripotency and improving understanding of the embryo development of domestic animals. | ko_KR |
dc.description.sponsorship | This work was supported by the BK21 Plus Program and the National Research Foundation of Korea (NRF) Grant funded by the Korea government (NRF2019R1C1C1004514), and partially supported by Grants from the Agenda Program of Rural Development Administration, Republic of Korea (No. PJ01362402). Funding is used to cover laboratory expenses, sample preparation, and sequencing. These funding agencies have no role in research design, data collection, analysis of results, or manuscript writing. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BMC | ko_KR |
dc.subject | Pig embryonic stem cells | - |
dc.subject | RNA-seq | - |
dc.subject | Transcriptome | - |
dc.subject | In vitro fertilized embryo | - |
dc.subject | Parthenogenetic embryo | - |
dc.subject | Preimplantation embryo | - |
dc.title | Transcriptome profiling of pluripotent pig embryonic stem cells originating from uni- and biparental embryos | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 최광환 | - |
dc.contributor.AlternativeAuthor | 이동경 | - |
dc.contributor.AlternativeAuthor | 오종남 | - |
dc.contributor.AlternativeAuthor | 김승훈 | - |
dc.contributor.AlternativeAuthor | 이민균 | - |
dc.contributor.AlternativeAuthor | 김성우 | - |
dc.contributor.AlternativeAuthor | 이창규 | - |
dc.identifier.doi | doi.org/10.1186/s13104-020-04987-6 | - |
dc.citation.journaltitle | BMC Research Notes | ko_KR |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s) | - |
dc.date.updated | 2020-06-17T13:15:07Z | - |
dc.citation.number | 1 | ko_KR |
dc.citation.startpage | 144 | ko_KR |
dc.citation.volume | 13 | ko_KR |
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