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Association of carotid and intracranial stenosis with Alzheimers disease biomarkers
DC Field | Value | Language |
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dc.contributor.author | Kang, Koung Mi | - |
dc.contributor.author | Byun, Min Soo | - |
dc.contributor.author | Lee, Jun Ho | - |
dc.contributor.author | Yi, Dahyun | - |
dc.contributor.author | Choi, Hye Jeong | - |
dc.contributor.author | Lee, Eunjung | - |
dc.contributor.author | Lee, Younghwa | - |
dc.contributor.author | Lee, Jun-Young | - |
dc.contributor.author | Kim, Yu Kyeong | - |
dc.contributor.author | Sohn, Bo Kyung | - |
dc.contributor.author | Sohn, Chul-Ho | - |
dc.contributor.author | Lee, Dong Young | - |
dc.date.accessioned | 2020-09-22T06:22:07Z | - |
dc.date.available | 2020-09-22T15:24:10Z | - |
dc.date.issued | 2020-09-10 | - |
dc.identifier.citation | Alzheimer's Research & Therapy. 2020 Sep 10;12(1):106 | ko_KR |
dc.identifier.issn | 1758-9193 | - |
dc.identifier.uri | https://hdl.handle.net/10371/168951 | - |
dc.description.abstract | Background
To clarify whether atherosclerosis of the carotid and intracranial arteries is related to Alzheimers disease (AD) pathology in vivo, we investigated the associations of carotid and intracranial artery stenosis with cerebral beta-amyloid (Aβ) deposition and neurodegeneration in middle- and old-aged individuals. Given different variations of the pathologies between cognitive groups, we focused separately on cognitively normal (CN) and cognitively impaired (CI) groups. Methods A total of 281 CN and 199 CI (mild cognitive impairment and AD dementia) subjects underwent comprehensive clinical assessment, [11C] Pittsburgh compound B-positron emission tomography, and magnetic resonance (MR) imaging including MR angiography. We evaluated extracranial carotid and intracranial arteries for the overall presence, severity (i.e., number and degree of narrowing), and location of stenosis. Results We found no associations between carotid and intracranial artery stenosis and cerebral Aβ burden in either the CN or the CI group. In terms of neurodegeneration, exploratory univariable analyses showed associations between the presence and severity of stenosis and regional neurodegeneration biomarkers (i.e., reduced hippocampal volume [HV] and cortical thickness in the AD-signature regions) in both the CN and CI groups. In confirmatory multivariable analyses controlling for demographic covariates and diagnosis, the association between number of stenotic intracranial arteries ≥ 2 and reduced HV in the CI group remained significant. Conclusions Neither carotid nor intracranial artery stenosis appears to be associated with brain Aβ burden, while intracranial artery stenosis is related to amyloid-independent neurodegeneration, particularly hippocampal atrophy. | ko_KR |
dc.description.sponsorship | This study was supported by a grant from the Ministry of Science and ICT, Republic of Korea (grant nos. NRF-2014M3C7A1046042, 2017R1A2B2008412, and 2018M3C7A1056888); by a grant of the Korea Health Technology R&D
Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant nos. HI18C0630 and HI19C0149); by a grant no. 04-20190500 from the SNUH Research Fund; and by a grant no. 06-20191860 from the Scientific Research Fund of the Korean Society of Magnetic Resonance in Medicine (2019). The funder had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BMC | ko_KR |
dc.subject | Alzheimer’s disease | - |
dc.subject | Amyloid beta | - |
dc.subject | Neurodegeneration | - |
dc.subject | Atherosclerosis | - |
dc.subject | Intracranial stenosis | - |
dc.subject | Carotid stenosis | - |
dc.subject | Cognitive impairment | - |
dc.title | Association of carotid and intracranial stenosis with Alzheimers disease biomarkers | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 강경미 | - |
dc.contributor.AlternativeAuthor | 변민수 | - |
dc.contributor.AlternativeAuthor | 이준호 | - |
dc.contributor.AlternativeAuthor | 이다현 | - |
dc.contributor.AlternativeAuthor | 최혜정 | - |
dc.contributor.AlternativeAuthor | 이은정 | - |
dc.contributor.AlternativeAuthor | 이영화 | - |
dc.contributor.AlternativeAuthor | 이준영 | - |
dc.contributor.AlternativeAuthor | 김유경 | - |
dc.contributor.AlternativeAuthor | 손보경 | - |
dc.contributor.AlternativeAuthor | 손철호 | - |
dc.contributor.AlternativeAuthor | 이동영 | - |
dc.identifier.doi | doi.org/10.1186/s13195-020-00675-6 | - |
dc.citation.journaltitle | Alzheimer's Research & Therapy | ko_KR |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s) | - |
dc.date.updated | 2020-09-13T03:15:10Z | - |
dc.citation.number | 1 | ko_KR |
dc.citation.startpage | 106 | ko_KR |
dc.citation.volume | 12 | ko_KR |
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