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Bioresorbable Electronic Implants: History, Materials, Fabrication, Devices, and Clinical Applications

Cited 29 time in Web of Science Cited 28 time in Scopus
Authors
Cha, Gi Doo; Kang, Dayoung; Lee, Jongha; Kim, Dae-Hyeong
Issue Date
2019-06
Citation
Advanced healthcare materials, Vol.8 No.11, p. 1801660
Keywords
bioresorbable electronicsbioresorbable materialsimplantable devicesmedical implantstransient electronics
Abstract
Medical implants, either passive implants for structural support or implantable devices with active electronics, have been widely used for the diagnosis and treatment of various diseases and clinical issues. These implants offer various functions, including mechanical support of biological structures in orthopedic and dental applications, continuous electrophysiological monitoring and feedback of electrical stimulation in neuronal and cardiac applications, and controlled drug delivery while maintaining arterial structure in drug-eluting stents. Although these implants exhibit long-term biocompatibility, surgery for their retrieval is often required, which imposes physical, biological, and economical burdens on the patients. Therefore, as an alternative to such secondary surgeries, bioresorbable implants that disappear after a certain period of time inside the body, including bioresorbable active electronics, have been highlighted recently. This review first discusses the historical background of medical implants and briefly define related terminology. Representative examples of non-degradable medical implants for passive structural support and/or for diagnosis and therapy with active electronics are also provided. Then, recent progress in bioresorbable active implants composed of biosignal sensors, actuators for therapeutics, wireless power supply components, and their integrated systems are reviewed. Finally, clinical applications of these bioresorbable electronic implants are exemplified with brief conclusion and future outlook.
ISSN
2192-2640
URI
https://hdl.handle.net/10371/171737
DOI
https://doi.org/10.1002/adhm.201801660
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College of Engineering/Engineering Practice School (공과대학/대학원)Dept. of Chemical and Biological Engineering (화학생물공학부)Journal Papers (저널논문_화학생물공학부)
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