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RNA interference in functional genomics and medicine
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, VN | - |
dc.date.accessioned | 2021-01-31T08:13:19Z | - |
dc.date.available | 2021-01-31T08:13:19Z | - |
dc.date.created | 2020-07-16 | - |
dc.date.issued | 2003-06 | - |
dc.identifier.citation | Journal of Korean Medical Science, Vol.18 No.3, pp.309-318 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.other | 106940 | - |
dc.identifier.uri | https://hdl.handle.net/10371/171914 | - |
dc.description.abstract | RNA interference (RNAi) is the sequence-specific gene silencing induced by double-stranded RNA (dsRNA). Being a highly specific and efficient knockdown technique, RNAi not only provides a powerful tool for functional genomics but also holds a promise for gene therapy. The key player in RNAi is small RNA (similar to22-nt) termed siRNA. Small RNAs are involved not only in RNAi but also in basic cellular processes, such as developmental control and heterochromatin formation. The interesting biology as well as the remarkable technical value has been drawing widespread attention to this exciting new field. | - |
dc.language | 영어 | - |
dc.publisher | 대한의학회 | - |
dc.title | RNA interference in functional genomics and medicine | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 김빛내리 | - |
dc.identifier.doi | 10.3346/jkms.2003.18.3.309 | - |
dc.citation.journaltitle | Journal of Korean Medical Science | - |
dc.identifier.wosid | 000183897900001 | - |
dc.identifier.scopusid | 2-s2.0-0346433892 | - |
dc.citation.endpage | 318 | - |
dc.citation.number | 3 | - |
dc.citation.startpage | 309 | - |
dc.citation.volume | 18 | - |
dc.identifier.sci | 000183897900001 | - |
dc.identifier.kciid | ART000919925 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Kim, VN | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | DOUBLE-STRANDED-RNA | - |
dc.subject.keywordPlus | VIRUS TYPE-1 REPLICATION | - |
dc.subject.keywordPlus | HEPATITIS-B-VIRUS | - |
dc.subject.keywordPlus | VECTOR-BASED RNAI | - |
dc.subject.keywordPlus | MAMMALIAN-CELLS | - |
dc.subject.keywordPlus | CAENORHABDITIS-ELEGANS | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | C-ELEGANS | - |
dc.subject.keywordPlus | HIV-1 INFECTION | - |
dc.subject.keywordPlus | ANTISENSE RNA | - |
dc.subject.keywordAuthor | RNA interference (RNAi) | - |
dc.subject.keywordAuthor | RNA, small interfering (siRNA) | - |
dc.subject.keywordAuthor | microRNAs (miRNA) | - |
dc.subject.keywordAuthor | small hairpin RNA (shRNA) | - |
dc.subject.keywordAuthor | mRNA degradation | - |
dc.subject.keywordAuthor | translation | - |
dc.subject.keywordAuthor | functional genomics | - |
dc.subject.keywordAuthor | gene therapy | - |
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