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Regulation of ApC/EBP mRNA by the Aplysia AU-rich element-binding protein, ApELAV, and its effects on 5-hydroxytryptamine-induced long-term facilitation
DC Field | Value | Language |
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dc.contributor.author | Yim, Se‐Jeong | - |
dc.contributor.author | Lee, Yong‐Seok | - |
dc.contributor.author | Lee, Jin‐A | - |
dc.contributor.author | Chang, Deok‐Jin | - |
dc.contributor.author | Han, Jin‐Hee | - |
dc.contributor.author | Kim, Hyoung | - |
dc.contributor.author | Park, Hyungju | - |
dc.contributor.author | Jun, Heejung | - |
dc.contributor.author | Kim, V. Narry | - |
dc.contributor.author | Kaang, Bong‐Kiun | - |
dc.date.accessioned | 2021-01-31T08:13:32Z | - |
dc.date.available | 2021-01-31T08:13:32Z | - |
dc.date.created | 2020-07-16 | - |
dc.date.issued | 2006-07 | - |
dc.identifier.citation | Journal of Neurochemistry, Vol.98 No.2, pp.420-429 | - |
dc.identifier.issn | 0022-3042 | - |
dc.identifier.other | 106992 | - |
dc.identifier.uri | https://hdl.handle.net/10371/171918 | - |
dc.description.abstract | Aplysia CCAAT enhancer-binding protein (ApC/EBP), a key molecular switch in 5-hydroxytryptamine (5-HT)-induced long-term facilitation of Aplysia, is quickly and transiently expressed in response to a 5-HT stimulus, but the mechanism underlying this dynamic expression profile remains obscure. Here, we report that the dynamic expression of ApC/EBP during long-term facilitation is regulated at the post-transcriptional level by AU-rich element (ARE)-binding proteins. We found that the 3'UTR of ApC/EBP mRNA contains putative sequences for ARE, which is a representative post-transcriptional cis-acting regulatory element that modulates the stability and/or the translatability of a distinct subset of labile mRNAs. We cloned the Aplysia homologue of embryonic lethal abnormal visual system homologue (ELAV/Hu) protein, one of the best-studied RNA-binding proteins that associate with ARE, and elucidated the involvement of Aplysia ELAV/Hu protein in ApC/EBP gene expressional regulation. Cloned Aplysia ELAV/Hu protein, Aplysia embryonic lethal abnormal visual system (ApELAV), bound to an AU-rich region within the 3'UTR of ApC/EBP mRNA. Additionally, ApELAV controlled the expression of ApC/EBP 3'UTR-containing reporter gene by functioning as a stability-enhancing factor. In particular, 5-HT-induced long-term facilitation was impaired when the AU-rich region within the 3'UTR of ApC/EBP was over-expressed, which suggests the significance of this region in 5-HT-induced ApC/EBP expression, and in the resultant formation of long-term facilitation. Our results imply that the Aplysia ARE-binding protein, ApELAV, can regulate ApC/EBP gene expression at the mRNA level, and accordingly, ARE-mediated post-transcriptional mechanism may serve a crucial function in regulating the expression of ApC/EBP in response to a 5-HT stimulus. | - |
dc.language | 영어 | - |
dc.publisher | Blackwell Publishing Inc. | - |
dc.title | Regulation of ApC/EBP mRNA by the Aplysia AU-rich element-binding protein, ApELAV, and its effects on 5-hydroxytryptamine-induced long-term facilitation | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 김빛내리 | - |
dc.identifier.doi | 10.1111/j.1471-4159.2006.03887.x | - |
dc.citation.journaltitle | Journal of Neurochemistry | - |
dc.identifier.wosid | 000238487000011 | - |
dc.identifier.scopusid | 2-s2.0-33746515063 | - |
dc.citation.endpage | 429 | - |
dc.citation.number | 2 | - |
dc.citation.startpage | 420 | - |
dc.citation.volume | 98 | - |
dc.identifier.sci | 000238487000011 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kim, V. Narry | - |
dc.contributor.affiliatedAuthor | Kaang, Bong‐Kiun | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ELAV-LIKE PROTEIN | - |
dc.subject.keywordPlus | POSTTRANSCRIPTIONAL REGULATION | - |
dc.subject.keywordPlus | NEURONAL DIFFERENTIATION | - |
dc.subject.keywordPlus | SELECTIVE DEGRADATION | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | NERVOUS-SYSTEM | - |
dc.subject.keywordPlus | UP-REGULATION | - |
dc.subject.keywordPlus | HUR | - |
dc.subject.keywordPlus | STABILITY | - |
dc.subject.keywordPlus | LOCALIZATION | - |
dc.subject.keywordAuthor | CCAAT enhancer-binding protein | - |
dc.subject.keywordAuthor | Aplysia | - |
dc.subject.keywordAuthor | AU-rich element (ARE)-binding protein | - |
dc.subject.keywordAuthor | long-term facilitation | - |
dc.subject.keywordAuthor | memory | - |
dc.subject.keywordAuthor | synaptic plasticity | - |
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