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Posttranscriptional Crossregulation between Drosha and DGCR8

Cited 292 time in Web of Science Cited 299 time in Scopus
Authors
Han, Jinju; Pedersen, Jakob S.; Kwon, S. Chul; Belair, Cassandra D.; Kim, Young-Kook; Yeom, Kyu-Hyeon; Yang, Woo-Young; Haussler, David; Blelloch, Robert; Kim, V. Narry
Issue Date
2009-01
Citation
Cell, Vol.136 No.1, pp.75-84
Abstract
The Drosha-DGCR8 complex, also known as Microprocessor, is essential for microRNA (miRNA) maturation. Drosha functions as the catalytic subunit, while DGCR8 (also known as Pasha) recognizes the RNA substrate. Although the action mechanism of this complex has been intensively studied, it remains unclear how Drosha and DGCR8 are regulated and if these proteins have any additional role(s) apart from miRNA processing. Here, we report that Drosha and DGCR8 regulate each other posttranscriptionally. The Drosha-DGCR8 complex cleaves the hairpin structures embedded in the DGCR8 mRNA and thereby destabilizes the mRNA. We further find that DGCR8 stabilizes the Drosha protein via protein-protein interaction. This crossregulation between Drosha and DGCR8 may contribute to the homeostatic control of miRNA biogenesis. Furthermore, microarray analyses suggest that a number of mRNAs may be downregulated in a Microprocessor-dependent, miRNA-independent manner. Our study reveals a previously unsuspected function of Microprocessor in mRNA stability control.
ISSN
0092-8674
URI
https://hdl.handle.net/10371/171928
DOI
https://doi.org/10.1016/j.cell.2008.10.053
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College of Natural Sciences (자연과학대학)Dept. of Biological Sciences (생명과학부)Journal Papers (저널논문_생명과학부)
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