Beyond ubiquitination: proteolytic and nonproteolytic roles of HOS1
- Jung, Jae-Hoon; Lee, Hyo-Jun; Park, Mi-Jeong; Park, Chung-Mo
- Issue Date
- Trends in Plant Science, Vol.19 No.8, pp.538-545
- chromatin remodeling; circadian clock; E3 ubiquitin ligase; HOS1; mRNA export; photoperiodic flowering
- The E3 ubiquitin ligase HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENES 1 (HOS1) functions as a cold signaling attenuator by degrading the INDUCER OF CBF EXPRESSION 1 transcription factor, which is a key regulator of the cold-induced transcriptome and freezing tolerance in plants. Recent studies demonstrate that HOS1 also plays nonproteolytic roles in gene expression regulation. HOS1 acts as a chromatin remodeling factor that modulates FLOWERING LOCUS C chromatin in cold regulation of flowering time. It associates with the nuclear pore complex to facilitate nucleocytoplasmic mRNA export to maintain circadian periodicity over a range of light and temperature conditions. In this review, we summarize recent advances in molecular mechanisms underlying HOS1 function during plant development in response to fluctuating environmental conditions.
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