Browse

Engineering structures and functions of mesenchymal stem cells by suspended large-area graphene nanopatterns

Cited 9 time in Web of Science Cited 9 time in Scopus
Authors
Kim, Jangho; Bae, Won-Gyu; Park, Subeom; Kim, Yeon Ju; Jo, Insu; Park, Sunho; Jeon, Noo Li; Kwak, Woori; Choi, Seoae; Park, Jooyeon; Kim, Hong Nam; Choi, Kyoung Soon; Seonwoo, Hoon; Choung, Yun-Hoon; Choung, Pill-Hoon; Hong, Byung Hee; Chung, Jong Hoon
Issue Date
2016-09
Citation
2D Materials, Vol.3 No.3, p. 035013
Keywords
large area graphenenanopatternscaffoldstem celltissue engineering
Abstract
Inspired by the hierarchical nanofibrous and highly oriented structures of natural extracellular matrices, we report a rational design of chemical vapor deposition graphene-anchored scaffolds that provide both physical and chemical cues in a multilayered organization to control the adhesion and functions of cells for regenerative medicine. These hierarchical platforms are fabricated by transferring large graphene film onto nanogroove patterns. The top graphene layer exhibits planar morphology with slight roughness (similar to 20 nm between peaks) due to the underlying topography, which results in a suspended structure between the nanoridges. We demonstrate that the adhesion and differentiation of human mesenchymal stem cells were sensitively controlled and enhanced by the both the nanotopography and graphene cues in our scaffolds. Our results indicate that the layered physical and chemical cues can affect the apparent cell behaviors, and can synergistically enhance cell functionality. Therefore, these suspended graphene platforms may be used to advance regenerative medicine.
ISSN
2053-1583
URI
https://hdl.handle.net/10371/172114
DOI
https://doi.org/10.1088/2053-1583/3/3/035013
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Natural Sciences (자연과학대학)Dept. of Chemistry (화학부)Journal Papers (저널논문_화학부)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse