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Engineering structures and functions of mesenchymal stem cells by suspended large-area graphene nanopatterns
DC Field | Value | Language |
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dc.contributor.author | Kim, Jangho | - |
dc.contributor.author | Bae, Won-Gyu | - |
dc.contributor.author | Park, Subeom | - |
dc.contributor.author | Kim, Yeon Ju | - |
dc.contributor.author | Jo, Insu | - |
dc.contributor.author | Park, Sunho | - |
dc.contributor.author | Jeon, Noo Li | - |
dc.contributor.author | Kwak, Woori | - |
dc.contributor.author | Choi, Seoae | - |
dc.contributor.author | Park, Jooyeon | - |
dc.contributor.author | Kim, Hong Nam | - |
dc.contributor.author | Choi, Kyoung Soon | - |
dc.contributor.author | Seonwoo, Hoon | - |
dc.contributor.author | Choung, Yun-Hoon | - |
dc.contributor.author | Choung, Pill-Hoon | - |
dc.contributor.author | Hong, Byung Hee | - |
dc.contributor.author | Chung, Jong Hoon | - |
dc.date.accessioned | 2021-01-31T08:26:16Z | - |
dc.date.available | 2021-01-31T08:26:16Z | - |
dc.date.created | 2018-01-10 | - |
dc.date.created | 2018-01-10 | - |
dc.date.issued | 2016-09 | - |
dc.identifier.citation | 2D Materials, Vol.3 No.3, p. 035013 | - |
dc.identifier.issn | 2053-1583 | - |
dc.identifier.other | 10197 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172114 | - |
dc.description.abstract | Inspired by the hierarchical nanofibrous and highly oriented structures of natural extracellular matrices, we report a rational design of chemical vapor deposition graphene-anchored scaffolds that provide both physical and chemical cues in a multilayered organization to control the adhesion and functions of cells for regenerative medicine. These hierarchical platforms are fabricated by transferring large graphene film onto nanogroove patterns. The top graphene layer exhibits planar morphology with slight roughness (similar to 20 nm between peaks) due to the underlying topography, which results in a suspended structure between the nanoridges. We demonstrate that the adhesion and differentiation of human mesenchymal stem cells were sensitively controlled and enhanced by the both the nanotopography and graphene cues in our scaffolds. Our results indicate that the layered physical and chemical cues can affect the apparent cell behaviors, and can synergistically enhance cell functionality. Therefore, these suspended graphene platforms may be used to advance regenerative medicine. | - |
dc.language | 영어 | - |
dc.publisher | Institute of Physics Publishing (IOP) | - |
dc.title | Engineering structures and functions of mesenchymal stem cells by suspended large-area graphene nanopatterns | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 홍병희 | - |
dc.identifier.doi | 10.1088/2053-1583/3/3/035013 | - |
dc.citation.journaltitle | 2D Materials | - |
dc.identifier.wosid | 000383872600003 | - |
dc.identifier.scopusid | 2-s2.0-84992364736 | - |
dc.citation.number | 3 | - |
dc.citation.startpage | 035013 | - |
dc.citation.volume | 3 | - |
dc.identifier.sci | 000383872600003 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Jeon, Noo Li | - |
dc.contributor.affiliatedAuthor | Choung, Pill-Hoon | - |
dc.contributor.affiliatedAuthor | Hong, Byung Hee | - |
dc.contributor.affiliatedAuthor | Chung, Jong Hoon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | FOCAL ADHESION KINASE | - |
dc.subject.keywordPlus | GAP-JUNCTION BLOCKAGE | - |
dc.subject.keywordPlus | OSTEOGENIC DIFFERENTIATION | - |
dc.subject.keywordPlus | REGENERATIVE MEDICINE | - |
dc.subject.keywordPlus | NEURONAL DIFFERENTIATION | - |
dc.subject.keywordPlus | LINEAGE | - |
dc.subject.keywordPlus | NANOTOPOGRAPHY | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | COMMITMENT | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordAuthor | large area graphene | - |
dc.subject.keywordAuthor | nanopattern | - |
dc.subject.keywordAuthor | scaffold | - |
dc.subject.keywordAuthor | stem cell | - |
dc.subject.keywordAuthor | tissue engineering | - |
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