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Graphene for Controlled and Accelerated Osteogenic Differentiation of Human Mesenchymal Stem Cells

Cited 621 time in Web of Science Cited 646 time in Scopus
Authors
Nayak, Tapas R.; Andersen, Henrik; Makam, Venkata S.; Khaw, Clement; Bae, Sukang; Xu, Xiangfan; Ee, Pui-Lai R.; Ahn, Jong-Hyun; Hong, Byung Hee; Pastorin, Giorgia; Oezyilmaz, Barbaros
Issue Date
2011-06
Citation
ACS Nano, Vol.5 No.6, pp.4670-4678
Keywords
graphenemesenchymal stem cellscell differentiationboneosteogenesis
Abstract
Current tissue engineering approaches combine different scaffold materials with living cells to provide biological substitutes that can repair and eventually improve tissue functions. Both natural and synthetic materials have been fabricated for transplantation of stem cells and their specific differentiation Into muscles, bones, and cartilages. One of the key objectives for bone regeneration therapy to be successful Is to direct stem cells' proliferation and to accelerate their differentiation in a controlled manner through the use of growth factors and osteogenic inducers. Here we show that graphene provides a promising biocompatible scaffold that does not hamper the proliferation of human mesenchymal stem cells (hMSCs) and accelerates their specific differentiation into bone cells. The differentiation rate Is comparable to the one achieved with common growth factors, demonstrating graphene's potential for stem cell research.
ISSN
1936-0851
URI
https://hdl.handle.net/10371/172125
DOI
https://doi.org/10.1021/nn200500h
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College of Natural Sciences (자연과학대학)Dept. of Chemistry (화학부)Journal Papers (저널논문_화학부)
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