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Anti-ulcer actions of phytosphingosine hydrochloride in different experimental rat ulcer models
DC Field | Value | Language |
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dc.contributor.author | Baek, SW | - |
dc.contributor.author | Kim, NK | - |
dc.contributor.author | Jin, HJ | - |
dc.contributor.author | Koh, CW | - |
dc.contributor.author | Kim, CK | - |
dc.contributor.author | Kwon, OH | - |
dc.contributor.author | Kim, JS | - |
dc.contributor.author | Cho, MH | - |
dc.contributor.author | Park, CK | - |
dc.date.accessioned | 2021-01-31T08:38:33Z | - |
dc.date.available | 2021-01-31T08:38:33Z | - |
dc.date.created | 2018-04-11 | - |
dc.date.issued | 2005 | - |
dc.identifier.citation | Arzneimittel-Forschung/Drug Research, Vol.55 No.8, pp.461-465 | - |
dc.identifier.issn | 0004-4172 | - |
dc.identifier.other | 31782 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172312 | - |
dc.description.abstract | The gastroprotective activity of phytosphingosine hydrochloride (PS-HCI, CAS 554-62-1) was assessed in four different rat models of experimentally induced gastric ulcer. Various doses (2.5-10 mg/kg) of PS-HCI were orally administered to rats 30 min before the treatment with HCI/ethanol, indometacin, cysteamine, or to rats with ligated pylorus. Oral administration of PS-HCI (2.5-10 mg/kg) to rats prevented the acute ulcer formation in 4 different types of ulcer in a dose-dependent manner as follows: (1) HCI/ethanol-induced gastric mucosal membrane lesions (20.1-47.8% inhibition), (2) indometacin-induced gastric mucosal membrane lesions (4.6-31.9% inhibition), (3) duodenal ulcer induced by cysteamine (10-20% inhibition), (4) gastric secretion and ulceration following pylorus ligation (33.3-61.9% inhibition). These results indicate that PS-HCI may be useful for the prevention of gastric ulcer. | - |
dc.language | 영어 | - |
dc.publisher | Editio Cantor Verlag | - |
dc.title | Anti-ulcer actions of phytosphingosine hydrochloride in different experimental rat ulcer models | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 조명행 | - |
dc.citation.journaltitle | Arzneimittel-Forschung/Drug Research | - |
dc.identifier.wosid | 000231686400006 | - |
dc.identifier.scopusid | 2-s2.0-23944505977 | - |
dc.citation.endpage | 465 | - |
dc.citation.number | 8 | - |
dc.citation.startpage | 461 | - |
dc.citation.volume | 55 | - |
dc.identifier.sci | 000231686400006 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Cho, MH | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | GASTRIC-MUCOSAL DAMAGE | - |
dc.subject.keywordPlus | PROSTAGLANDINS | - |
dc.subject.keywordPlus | INDOMETHACIN | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordAuthor | Anti-ulcer drug | - |
dc.subject.keywordAuthor | CAS 554-62-1 | - |
dc.subject.keywordAuthor | phytosphingosine hydrochloride, anti-ulcer action, rat | - |
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