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Pharmacokinetics and tissue distribution of B-domain deleted recombinant human factor VIII (GC-γ AHF) in rats
DC Field | Value | Language |
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dc.contributor.author | Mar, W. | - |
dc.contributor.author | Kim, K.N. | - |
dc.contributor.author | Choi, E.W. | - |
dc.contributor.author | Fang, M.Z. | - |
dc.contributor.author | Kwak, H.I. | - |
dc.contributor.author | Kim, M.Y. | - |
dc.contributor.author | Son, J.W. | - |
dc.contributor.author | Shin, M.K. | - |
dc.contributor.author | Bae, M.O. | - |
dc.contributor.author | Lee, B.J. | - |
dc.contributor.author | Lee, H.J. | - |
dc.contributor.author | Byun, T.H. | - |
dc.contributor.author | Park, S.Y. | - |
dc.contributor.author | Chun, B.H. | - |
dc.contributor.author | Byun, J.H. | - |
dc.contributor.author | Ahn, G.H. | - |
dc.contributor.author | Lee, Y.J. | - |
dc.contributor.author | Cho, M.H. | - |
dc.date.accessioned | 2021-01-31T08:38:42Z | - |
dc.date.available | 2021-01-31T08:38:42Z | - |
dc.date.created | 2018-01-10 | - |
dc.date.issued | 2000 | - |
dc.identifier.citation | Asia Pacific Journal of Pharmacology, Vol.14 No.1-2, pp.7-10 | - |
dc.identifier.issn | 0217-9687 | - |
dc.identifier.other | 18151 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172314 | - |
dc.description.abstract | Recombinant human factor VIII is a glycoprotein that is used for the treatment of hemophilia A. The B-domain deleted recombinant factor VIII, GC-γ AHF, was newly developed by the Korea Green Cross Pharmaceutical Company. To investigate its pharmacokinetics and tissue distribution, GC-γ AHF was labelled with 125I. Following a single intravenous administration of [125I]GC-γ AHF to rats, plasma concentrations of [125I]GC-γ AHF versus time curves were analyzed and the pharmacokinetic parameters were estimated. The data obtained from plasma as fitted with a two compartment open model and mean residence time (MRT) was 123.83 min. The half life of radioactivity associated with [125I]GC-γ AHF in plasma was 13.25 min and other pharmacokinetic parameters of GC-γ AHF were as follows: Clearance, 23 ml/min/kg; steady-state volume of distribution, 2.84 l/kg. A larger proportion of the administered radioactivity was excreted via urine than via faeces and the total administered dose recovered in excreta was 88.2%. The total levels of radioactivity were higher in liver, stomach and small intestine than in other tissues. These studies suggest that the pharmacokinetic data of GC-γ AHF obtained from rats in the present study would be useful for preclinical evaluation of the newly developed genetically engineered human protein. | - |
dc.language | 영어 | - |
dc.publisher | Singapore University Press | - |
dc.title | Pharmacokinetics and tissue distribution of B-domain deleted recombinant human factor VIII (GC-γ AHF) in rats | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 조명행 | - |
dc.citation.journaltitle | Asia Pacific Journal of Pharmacology | - |
dc.identifier.scopusid | 2-s2.0-0033799113 | - |
dc.citation.endpage | 10 | - |
dc.citation.number | 1-2 | - |
dc.citation.startpage | 7 | - |
dc.citation.volume | 14 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Mar, W. | - |
dc.contributor.affiliatedAuthor | Cho, M.H. | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | potassium iodide | - |
dc.subject.keywordPlus | recombinant blood clotting factor 8 | - |
dc.subject.keywordPlus | animal experiment | - |
dc.subject.keywordPlus | animal model | - |
dc.subject.keywordPlus | animal tissue | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | drug distribution | - |
dc.subject.keywordPlus | drug excretion | - |
dc.subject.keywordPlus | drug feces level | - |
dc.subject.keywordPlus | drug half life | - |
dc.subject.keywordPlus | drug tissue level | - |
dc.subject.keywordPlus | drug uptake | - |
dc.subject.keywordPlus | drug urine level | - |
dc.subject.keywordPlus | female | - |
dc.subject.keywordPlus | hemophilia A | - |
dc.subject.keywordPlus | male | - |
dc.subject.keywordPlus | nonhuman | - |
dc.subject.keywordPlus | radioactivity | - |
dc.subject.keywordPlus | rat | - |
dc.subject.keywordAuthor | Haemophilia A | - |
dc.subject.keywordAuthor | Human factor VIII | - |
dc.subject.keywordAuthor | Pharmacokinetics | - |
dc.subject.keywordAuthor | Rats | - |
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