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Pharmacokinetics and tissue distribution of B-domain deleted recombinant human factor VIII (GC-γ AHF) in rats

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dc.contributor.authorMar, W.-
dc.contributor.authorKim, K.N.-
dc.contributor.authorChoi, E.W.-
dc.contributor.authorFang, M.Z.-
dc.contributor.authorKwak, H.I.-
dc.contributor.authorKim, M.Y.-
dc.contributor.authorSon, J.W.-
dc.contributor.authorShin, M.K.-
dc.contributor.authorBae, M.O.-
dc.contributor.authorLee, B.J.-
dc.contributor.authorLee, H.J.-
dc.contributor.authorByun, T.H.-
dc.contributor.authorPark, S.Y.-
dc.contributor.authorChun, B.H.-
dc.contributor.authorByun, J.H.-
dc.contributor.authorAhn, G.H.-
dc.contributor.authorLee, Y.J.-
dc.contributor.authorCho, M.H.-
dc.date.accessioned2021-01-31T08:38:42Z-
dc.date.available2021-01-31T08:38:42Z-
dc.date.created2018-01-10-
dc.date.issued2000-
dc.identifier.citationAsia Pacific Journal of Pharmacology, Vol.14 No.1-2, pp.7-10-
dc.identifier.issn0217-9687-
dc.identifier.other18151-
dc.identifier.urihttps://hdl.handle.net/10371/172314-
dc.description.abstractRecombinant human factor VIII is a glycoprotein that is used for the treatment of hemophilia A. The B-domain deleted recombinant factor VIII, GC-γ AHF, was newly developed by the Korea Green Cross Pharmaceutical Company. To investigate its pharmacokinetics and tissue distribution, GC-γ AHF was labelled with 125I. Following a single intravenous administration of [125I]GC-γ AHF to rats, plasma concentrations of [125I]GC-γ AHF versus time curves were analyzed and the pharmacokinetic parameters were estimated. The data obtained from plasma as fitted with a two compartment open model and mean residence time (MRT) was 123.83 min. The half life of radioactivity associated with [125I]GC-γ AHF in plasma was 13.25 min and other pharmacokinetic parameters of GC-γ AHF were as follows: Clearance, 23 ml/min/kg; steady-state volume of distribution, 2.84 l/kg. A larger proportion of the administered radioactivity was excreted via urine than via faeces and the total administered dose recovered in excreta was 88.2%. The total levels of radioactivity were higher in liver, stomach and small intestine than in other tissues. These studies suggest that the pharmacokinetic data of GC-γ AHF obtained from rats in the present study would be useful for preclinical evaluation of the newly developed genetically engineered human protein.-
dc.language영어-
dc.publisherSingapore University Press-
dc.titlePharmacokinetics and tissue distribution of B-domain deleted recombinant human factor VIII (GC-γ AHF) in rats-
dc.typeArticle-
dc.contributor.AlternativeAuthor조명행-
dc.citation.journaltitleAsia Pacific Journal of Pharmacology-
dc.identifier.scopusid2-s2.0-0033799113-
dc.citation.endpage10-
dc.citation.number1-2-
dc.citation.startpage7-
dc.citation.volume14-
dc.description.isOpenAccessN-
dc.contributor.affiliatedAuthorMar, W.-
dc.contributor.affiliatedAuthorCho, M.H.-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.subject.keywordPluspotassium iodide-
dc.subject.keywordPlusrecombinant blood clotting factor 8-
dc.subject.keywordPlusanimal experiment-
dc.subject.keywordPlusanimal model-
dc.subject.keywordPlusanimal tissue-
dc.subject.keywordPlusarticle-
dc.subject.keywordPluscontrolled study-
dc.subject.keywordPlusdrug distribution-
dc.subject.keywordPlusdrug excretion-
dc.subject.keywordPlusdrug feces level-
dc.subject.keywordPlusdrug half life-
dc.subject.keywordPlusdrug tissue level-
dc.subject.keywordPlusdrug uptake-
dc.subject.keywordPlusdrug urine level-
dc.subject.keywordPlusfemale-
dc.subject.keywordPlushemophilia A-
dc.subject.keywordPlusmale-
dc.subject.keywordPlusnonhuman-
dc.subject.keywordPlusradioactivity-
dc.subject.keywordPlusrat-
dc.subject.keywordAuthorHaemophilia A-
dc.subject.keywordAuthorHuman factor VIII-
dc.subject.keywordAuthorPharmacokinetics-
dc.subject.keywordAuthorRats-
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