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Deleterious effects in reproduction and developmental immunity elicited by pulmonary iron oxide nanoparticles

Cited 9 time in Web of Science Cited 9 time in Scopus
Authors
Park, Eun-Jung; Jeong, Uiseok; Kim, Younghun; Lee, Byoung-Seok; Cho, Myung-Haing; Go, You-Seok
Issue Date
2017-01
Citation
Environmental Research, Vol.152, pp.503-513
Keywords
Iron oxide nanoparticlesReproductionImmunotoxicityMortalitySex ratio
Abstract
With the extensive application of iron oxide nanoparticles (FeNPs), attention about their potential risks to human health is also rapidly raising, particularly in sensitive subgroups such as pregnant women and babies. In this study, we a single instilled intratracheally FeNPs (1, 2, and 4 mg/kg) to the male and female parent mice, mated, then assessed reproductive toxicity according to the modified OECD TG 421. During the pre-mating period (14 days), two female parent mice died at 4 mg/kg dose, and the body weight gain dose-dependently decreased in male and female parent mice exposed to FeNPs. Additionally, iron accumulation and the enhanced expression of MHC class II molecules were observed in the ovary and the testis of parent mice exposed to the highest dose of FeNPs, and the total sex ratio (male/female) of the offspring mice increased in the groups exposed to FeNPs. Following, we a single instilled intratracheally to their offspring mice with the same doses and evaluated the immunotoxic response on day 28. The increased mortality and significant hematological- and biochemical- changes were observed in offspring mice exposed at 4 mg/kg dose, especially in female mice. More interestingly, balance of the immune response was shifted to a different direction in male and female offspring mice. Taken together, we conclude that the NOAEL for reproductive and developmental toxicity of FeNPs may be lower than 2 mg/kg, and that female mice may show more sensitive response to FeNPs exposure than male mice. Furthermore, we suggest that further studies are necessary to identify causes of both the alteration in sex ratio of offspring mice and different immune response in male and female offspring mice.
ISSN
0013-9351
URI
https://hdl.handle.net/10371/172368
DOI
https://doi.org/10.1016/j.envres.2016.08.025
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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