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Carboxyl-terminal modulator protein induces apoptosis by regulating mitochondrial function in lung cancer cells
DC Field | Value | Language |
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dc.contributor.author | Hwang, Soon-Kyung | - |
dc.contributor.author | Minai-Tehrani, Arash | - |
dc.contributor.author | Yu, Kyeong-Nam | - |
dc.contributor.author | Chang, Seung-Hee | - |
dc.contributor.author | Kim, Ji-Eun | - |
dc.contributor.author | Lee, Kee-Ho | - |
dc.contributor.author | Park, Jongsun | - |
dc.contributor.author | Beck, George R., Jr. | - |
dc.contributor.author | Cho, Myung-Haing | - |
dc.date.accessioned | 2021-01-31T08:43:45Z | - |
dc.date.available | 2021-01-31T08:43:45Z | - |
dc.date.created | 2020-11-18 | - |
dc.date.issued | 2012-05 | - |
dc.identifier.citation | International Journal of Oncology, Vol.40 No.5, pp.1515-1524 | - |
dc.identifier.issn | 1019-6439 | - |
dc.identifier.other | 116663 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172399 | - |
dc.description.abstract | Serine/threonine protein kinase 13 (PKB/Akt) is involved in cell survival and growth. Carboxyl-terminal modulator protein (CTMP), a novel Akt binding partner, prevents Akt activation at the plasma membrane in response to various stimuli, and thus possesses a tumor suppressor-like function. In a previous study, we have demonstrated that CTMP inhibits tumor progression by facilitating apoptosis in a mouse lung cancer model. However, the precise mechanism of CTMP-induced apoptosis remains to be elucidated. The present study was performed to examine the role of CTMP in mitochondrial-mediated apoptosis and regulation of mitochondrial function in human lung carcinoma cells. Our results showed that CTMP altered mitochondrial morphology and caused the release of cytochrome c by inhibiting OPA1 expression. Additionally, CTMP facilitated mitochondrial-mediated apoptosis by inhibiting heat-shock protein 27 and preventing cytochrome c interaction with Apaf-1. Our data suggest that CTMP may therefore play a critical role in mitochondrial-mediated apoptosis in lung cancer cells. | - |
dc.language | 영어 | - |
dc.publisher | Demetrios A. Spandidos Ed. & Pub. | - |
dc.title | Carboxyl-terminal modulator protein induces apoptosis by regulating mitochondrial function in lung cancer cells | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 조명행 | - |
dc.identifier.doi | 10.3892/ijo.2011.1319 | - |
dc.citation.journaltitle | International Journal of Oncology | - |
dc.identifier.wosid | 000302273400022 | - |
dc.identifier.scopusid | 2-s2.0-84860298612 | - |
dc.citation.endpage | 1524 | - |
dc.citation.number | 5 | - |
dc.citation.startpage | 1515 | - |
dc.citation.volume | 40 | - |
dc.identifier.sci | 000302273400022 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Cho, Myung-Haing | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | CYTOCHROME-C | - |
dc.subject.keywordPlus | OPA1 | - |
dc.subject.keywordPlus | DYNAMICS | - |
dc.subject.keywordPlus | AKT | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | MORPHOLOGY | - |
dc.subject.keywordPlus | MEMBRANE | - |
dc.subject.keywordPlus | PKB/AKT | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordAuthor | CTMP | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordAuthor | mitochondria | - |
dc.subject.keywordAuthor | lung cancer cells | - |
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