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Gene Expression and Pulmonary Toxicity of Chitosan-graft-Polyethylenimine as Aerosol Gene Carrier
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kwon, Jung-Taek | - |
dc.contributor.author | Jiang, Hu-Lin | - |
dc.contributor.author | Minai-Tehrani, Arash | - |
dc.contributor.author | Woo, Chang Gyu | - |
dc.contributor.author | Choi, Mansoo | - |
dc.contributor.author | Cho, Chong-Su | - |
dc.contributor.author | Kim, Yeon-Soo | - |
dc.contributor.author | Cho, Myung-Haing | - |
dc.date.accessioned | 2021-01-31T08:44:10Z | - |
dc.date.available | 2021-01-31T08:44:10Z | - |
dc.date.created | 2018-01-10 | - |
dc.date.issued | 2013-03 | - |
dc.identifier.citation | Iranian Journal of Pharmaceutical Research, Vol.12 No.2, pp.281-286 | - |
dc.identifier.issn | 1735-0328 | - |
dc.identifier.other | 12785 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172407 | - |
dc.description.abstract | Chitosan-graft-polyethylenimine (CHI-g-PEI) copolymer has been used for the improvement of low transfection efficiency of chitosan. The present study aims to test the pulmonary toxicity and efficiency of CHI-g-PEI as an aerosol gene carrier. Mice were exposed to aerosol containing green-fluorescent protein (GFP)-polyethylenimine (PEI) or GFP-CHI-g-PEI complexes for 30 min during the development of our nose-only exposure chamber (NOEC) system. CHI-g-PEI-mediated aerosol delivery demonstrated 15.65% enhancement of the fluorescence intensity. Compared to PEI, CHI-g-PEI showed no significant pulmonary toxicity. In summary, using CHI-g-PEI is safe and shows high transfection in aerosol gene delivery to animals, and enhanced efficiency was achieved through our aerosol gene delivery system. Therefore, CHI-g-PEI and this system would be applicable to future study for aerosol gene therapy. | - |
dc.language | 영어 | - |
dc.publisher | Shaheed Behesti University of Medical Sciences and Health | - |
dc.title | Gene Expression and Pulmonary Toxicity of Chitosan-graft-Polyethylenimine as Aerosol Gene Carrier | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 조명행 | - |
dc.citation.journaltitle | Iranian Journal of Pharmaceutical Research | - |
dc.identifier.wosid | 000320508300004 | - |
dc.identifier.scopusid | 2-s2.0-84878941998 | - |
dc.citation.endpage | 286 | - |
dc.citation.number | 2 | - |
dc.citation.startpage | 281 | - |
dc.citation.volume | 12 | - |
dc.identifier.sci | 000320508300004 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Cho, Myung-Haing | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | TRANSFECTION EFFICIENCY | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | DELIVERY-SYSTEM | - |
dc.subject.keywordPlus | DNA COMPLEXES | - |
dc.subject.keywordPlus | PEI-DNA | - |
dc.subject.keywordPlus | NEBULIZATION | - |
dc.subject.keywordPlus | NEBULIZERS | - |
dc.subject.keywordPlus | SERUM | - |
dc.subject.keywordPlus | PH | - |
dc.subject.keywordAuthor | Aerosol delivery | - |
dc.subject.keywordAuthor | Chitosan | - |
dc.subject.keywordAuthor | Gene carrier | - |
dc.subject.keywordAuthor | Polyethylenimine | - |
dc.subject.keywordAuthor | Pulmonary toxicity | - |
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