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Serum immunoglobulin fused interferon-alpha inhibited tumor growth in athymic mice bearing colon 26 adenocarcinoma cells

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dc.contributor.authorKim, Jun Sung-
dc.contributor.authorYu, Kyeing Nam-
dc.contributor.authorNoh, Mi Suk-
dc.contributor.authorWoo, Min-Ah-
dc.contributor.authorPark, Sung-Jin-
dc.contributor.authorPark, Jin Hong-
dc.contributor.authorHua, Jin-
dc.contributor.authorCho, Hyun Sun-
dc.contributor.authorHwang, Soon Kyung-
dc.contributor.authorLee, Eun Sun-
dc.contributor.authorChung, Youn-Sun-
dc.contributor.authorChoi, In-Young-
dc.contributor.authorKwon, Se-Chang-
dc.contributor.authorCho, Myung-Haing-
dc.date.accessioned2021-01-31T08:47:25Z-
dc.date.available2021-01-31T08:47:25Z-
dc.date.issued2008-03-
dc.identifier.citationJournal of Veterinary Science, Vol.9 No.1, pp.45-50-
dc.identifier.issn1229-845X-
dc.identifier.other119213-
dc.identifier.urihttps://hdl.handle.net/10371/172459-
dc.description.abstractInterferon (IFN) has therapeutic potential for a wide range of infectious and proliferative disorders. However, the half-life of IFN is too short to have a stable therapeutic effect. To overcome this problem, serum immunoglobulin has been fused to IFN. In this study, the efficacy of serum immunoglobulin fused INFs (si-IFN1 and si-IFN2) was evaluated on athymic mice bearing colon 26 adenocarcinoma cells. Seven days after the implantation of tumor cells, each group of mice was injected once a week with si-IFN1 and si-IFN2 at two different concentrations (10 x : 30 mu g/kg and 50 x : 150 mu g/kg). A slight anti-tumoral effect was observed in all 10 x groups compared to the control. In the 50 x groups, however, si-IFN1 and si-IFN2 showed significant anti- tumoral effects compared to the control. To gain more information on the mechanisms associated with the decrease of tumor size, a Western blot assay of apoptosis-related molecules was performed. The protein expression of cytochrome c, caspase 9, 6, and 3 were increased by si-IFN1 and si-IFN2. These 2 IFNs also increased the expressions of p53, p21, Bax and Bad. Interestingly, si-IFN1 and si-IFN2 decreased the expression of VEGF-beta. Taken together, serum immunoglobulin fused IFNs increased therapeutic efficacy under current experimental condition.-
dc.subjectadenocarcinoma cell-
dc.subjectinterferon-
dc.subjectserum immunoglobulin-
dc.subjecttumor growth inhibition-
dc.titleSerum immunoglobulin fused interferon-alpha inhibited tumor growth in athymic mice bearing colon 26 adenocarcinoma cells-
dc.typeArticle-
dc.contributor.AlternativeAuthor조명행-
dc.identifier.doi10.4142/jvs.2008.9.1.45.-
dc.citation.journaltitleJournal of Veterinary Science-
dc.identifier.scopusid2-s2.0-45749111423-
dc.citation.endpage50-
dc.citation.number1-
dc.citation.startpage45-
dc.citation.volume9-
dc.identifier.rimsid119213-
dc.identifier.sci000253787300007-
dc.identifier.kciidART001240610-
dc.contributor.affiliatedAuthorCho, Myung-Haing-
Appears in Collections:
College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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