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Mannosylated chitosan nanoparticle-based cytokine gene therapy suppressed cancer growth in BALB/c mice bearing CT-26 carcinoma cells
DC Field | Value | Language |
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dc.contributor.author | Kim, Tae Hee | - |
dc.contributor.author | Jin, Hua | - |
dc.contributor.author | Kim, Hyun Woo | - |
dc.contributor.author | Cho, Myung-Haing | - |
dc.contributor.author | Cho, Chong Su | - |
dc.date.accessioned | 2021-01-31T08:48:08Z | - |
dc.date.available | 2021-01-31T08:48:08Z | - |
dc.date.created | 2018-04-11 | - |
dc.date.issued | 2006-07 | - |
dc.identifier.citation | Molecular Cancer Therapeutics, Vol.5 No.7, pp.1723-1732 | - |
dc.identifier.issn | 1535-7163 | - |
dc.identifier.other | 31415 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172472 | - |
dc.description.abstract | Cancer immunotherapy relies on the ability of the immune system to destroy tumor cells selectively and to elicit a long-lasting memory of such activity. Interleukin-1 2 (IL-12) is an immunomodulatory cytokine produced primarily by antigen-presenting cells, which play an important role in promoting Th1-type immune response and cell-mediated immunity. To augment the antitumor immune action by in vivo IL-12 gene delivery, mannosylated chitosan (MC) was prepared to induce mannose receptor-mediated endocytosis of IL-12 gene directly into dendritic cells which reside within the tumor. Upon characterization, MC was proven to be suitable for IL-12 gene delivery due to good physicochemical properties and low cytotoxicity. In addition, MC exhibited much enhanced IL-12 gene transfer efficiency to dendritic cells rather than chitosan itself in terms of the induction of murine IL-12 p70 and murine IFN-gamma. In animal studies, intratumoral injection of MC/plasmid encoding murine IL-12 complex into BALB/c mice bearing CT-26 carcinoma cells clearly suppressed tumor growth and angiogenesis, and significantly induced cell cycle arrest and apoptosis. Therefore, this study provides a new MC-mediated cytokine gene delivery system for cancer immunotherapy. | - |
dc.language | 영어 | - |
dc.publisher | American Association for Cancer Research | - |
dc.title | Mannosylated chitosan nanoparticle-based cytokine gene therapy suppressed cancer growth in BALB/c mice bearing CT-26 carcinoma cells | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 조명행 | - |
dc.identifier.doi | 10.1158/1535-7163.MCT-06-0540 | - |
dc.citation.journaltitle | Molecular Cancer Therapeutics | - |
dc.identifier.wosid | 000239682900011 | - |
dc.identifier.scopusid | 2-s2.0-33748318169 | - |
dc.citation.endpage | 1732 | - |
dc.citation.number | 7 | - |
dc.citation.startpage | 1723 | - |
dc.citation.volume | 5 | - |
dc.identifier.sci | 000239682900011 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Cho, Myung-Haing | - |
dc.contributor.affiliatedAuthor | Cho, Chong Su | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | POTENT ANTITUMOR IMMUNITY | - |
dc.subject.keywordPlus | DENDRITIC CELLS | - |
dc.subject.keywordPlus | TRANSFECTION EFFICIENCY | - |
dc.subject.keywordPlus | MANNOSE RECEPTOR | - |
dc.subject.keywordPlus | COLON-CARCINOMA | - |
dc.subject.keywordPlus | INTERLEUKIN-12 | - |
dc.subject.keywordPlus | IL-12 | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | ACTIVATION | - |
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