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Titanium dioxide nanoparticles induce endoplasmic reticulum stress-mediated autophagic cell death via mitochondria-associated endoplasmic reticulum membrane disruption in normal lung cells
DC Field | Value | Language |
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dc.contributor.author | Yu, Kyeong-Nam | - |
dc.contributor.author | Chang, Seung-Hee | - |
dc.contributor.author | Park, Soo Jin | - |
dc.contributor.author | Lim, Joohyun | - |
dc.contributor.author | Lee, Jinkyu | - |
dc.contributor.author | Yoon, Tae-Jong | - |
dc.contributor.author | Kim, Jun-Sung | - |
dc.contributor.author | Cho, Myung-Haing | - |
dc.date.accessioned | 2021-01-31T08:49:47Z | - |
dc.date.available | 2021-01-31T08:49:47Z | - |
dc.date.created | 2018-10-18 | - |
dc.date.issued | 2015-06 | - |
dc.identifier.citation | PLoS ONE, Vol.10 No.6, p. e0131208 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.other | 60518 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172503 | - |
dc.description.abstract | Nanomaterials are used in diverse fields including food, cosmetic, and medical industries. Titanium dioxide nanoparticles (TiO2-NP) are widely used, but their effects on biological systems and mechanism of toxicity have not been elucidated fully. Here, we report the toxicological mechanism of TiO2-NP in cell organelles. Human bronchial epithelial cells (16HBE14o-) were exposed to 50 and 100 mu g/mL TiO2-NP for 24 and 48 h. Our results showed that TiO2-NP induced endoplasmic reticulum (ER) stress in the cells and disrupted the mitochondria-associated endoplasmic reticulum membranes (MAMs) and calcium ion balance, thereby increasing autophagy. In contrast, an inhibitor of ER stress, tauroursodeoxycholic acid (TUDCA), mitigated the cellular toxic response, suggesting that TiO2-NP promoted toxicity via ER stress. This novel mechanism of TiO2-NP toxicity in human bronchial epithelial cells suggests that further exhaustive research on the harmful effects of these nanoparticles in relevant organisms is needed for their safe application. | - |
dc.language | 영어 | - |
dc.publisher | Public Library of Science | - |
dc.title | Titanium dioxide nanoparticles induce endoplasmic reticulum stress-mediated autophagic cell death via mitochondria-associated endoplasmic reticulum membrane disruption in normal lung cells | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 조명행 | - |
dc.identifier.doi | 10.1371/journal.pone.0131208 | - |
dc.citation.journaltitle | PLoS ONE | - |
dc.identifier.wosid | 000358150400085 | - |
dc.identifier.scopusid | 2-s2.0-84938629238 | - |
dc.citation.number | 6 | - |
dc.citation.startpage | e0131208 | - |
dc.citation.volume | 10 | - |
dc.identifier.sci | 000358150400085 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Lee, Jinkyu | - |
dc.contributor.affiliatedAuthor | Cho, Myung-Haing | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | ULTRAFINE | - |
dc.subject.keywordPlus | DAMAGE | - |
dc.subject.keywordPlus | CYTOTOXICITY | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | KINASE | - |
dc.subject.keywordPlus | INJURY | - |
dc.subject.keywordPlus | RATS | - |
dc.subject.keywordPlus | AMP | - |
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