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Zinc oxide nanoparticle induced autophagic cell death and mitochondrial damage via reactive oxygen species generation

DC Field Value Language
dc.contributor.authorYu, Kyeong-Nam-
dc.contributor.authorYoon, Tae-Jong-
dc.contributor.authorMinai-Tehrani, Arash-
dc.contributor.authorKim, Ji-Eun-
dc.contributor.authorPark, Soo Jin-
dc.contributor.authorJeong, Min Sook-
dc.contributor.authorHa, Shin-Woo-
dc.contributor.authorLee, Jin-Kyu-
dc.contributor.authorKim, Jun Sung-
dc.contributor.authorCho, Myung-Haing-
dc.date.accessioned2021-01-31T08:50:59Z-
dc.date.available2021-01-31T08:50:59Z-
dc.date.created2020-12-10-
dc.date.issued2013-06-
dc.identifier.citationToxicology in Vitro, Vol.27 No.4, pp.1187-1195-
dc.identifier.issn0887-2333-
dc.identifier.other118966-
dc.identifier.urihttps://hdl.handle.net/10371/172524-
dc.description.abstractZinc oxide nanoparticles (ZnO-np) are used in an increasing number of industrial products such as paint, coating and cosmetics, and in other biological applications. There have been many suggestions of a ZnO-np toxicity paradigm but the underlying molecular mechanisms about the toxicity of ZnO-np remain unclear. This study was done to determine the potential toxicity of ZnO-np and to assess the toxicity mechanism in normal skin cells. Synthesized ZnO-np generated reactive oxygen species (ROS), as determined by electron spin resonance. After uptake into cells, ZnO-np induced ROS in a concentration- and time-dependent manner. To demonstrate ZnO-np toxicity mechanism related to ROS, we detected abnormal autophagic vacuoles accumulation and mitochondria dysfunction after ZnO-np treatment. Furthermore mitochondria membrane potential and adenosine-5'-triphosphate (ATP) production are decreased for culture with ZnO-np. We conclude that ZnO-np leads to cell death through autophagic vacuole accumulation and mitochondria damage in normal skin cells via ROS induction. Accordingly, ZnO-np may cause toxicity and the results highlight and need for careful regulation of ZnO-np production and use. (C) 2013 Elsevier Ltd. All rights reserved.-
dc.language영어-
dc.publisherElsevier BV-
dc.titleZinc oxide nanoparticle induced autophagic cell death and mitochondrial damage via reactive oxygen species generation-
dc.typeArticle-
dc.contributor.AlternativeAuthor조명행-
dc.identifier.doi10.1016/j.tiv.2013.02.010-
dc.citation.journaltitleToxicology in Vitro-
dc.identifier.wosid000318838000001-
dc.identifier.scopusid2-s2.0-84875489407-
dc.citation.endpage1195-
dc.citation.number4-
dc.citation.startpage1187-
dc.citation.volume27-
dc.identifier.sci000318838000001-
dc.description.isOpenAccessN-
dc.contributor.affiliatedAuthorCho, Myung-Haing-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.subject.keywordPlusOXIDATIVE STRESS-
dc.subject.keywordPlusZNO NANOPARTICLES-
dc.subject.keywordPlusCANCER-
dc.subject.keywordPlusMECHANISM-
dc.subject.keywordPlusTOXICITY-
dc.subject.keywordPlusPROTEIN-
dc.subject.keywordPlusRESPONSES-
dc.subject.keywordAuthorZinc oxide nanoparticles-
dc.subject.keywordAuthorCytotoxicity-
dc.subject.keywordAuthorAutophagy-
dc.subject.keywordAuthorReactive oxygen species (ROS)-
dc.subject.keywordAuthorMitochondria damage-
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