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Zinc oxide nanoparticle induced autophagic cell death and mitochondrial damage via reactive oxygen species generation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yu, Kyeong-Nam | - |
dc.contributor.author | Yoon, Tae-Jong | - |
dc.contributor.author | Minai-Tehrani, Arash | - |
dc.contributor.author | Kim, Ji-Eun | - |
dc.contributor.author | Park, Soo Jin | - |
dc.contributor.author | Jeong, Min Sook | - |
dc.contributor.author | Ha, Shin-Woo | - |
dc.contributor.author | Lee, Jin-Kyu | - |
dc.contributor.author | Kim, Jun Sung | - |
dc.contributor.author | Cho, Myung-Haing | - |
dc.date.accessioned | 2021-01-31T08:50:59Z | - |
dc.date.available | 2021-01-31T08:50:59Z | - |
dc.date.created | 2020-12-10 | - |
dc.date.issued | 2013-06 | - |
dc.identifier.citation | Toxicology in Vitro, Vol.27 No.4, pp.1187-1195 | - |
dc.identifier.issn | 0887-2333 | - |
dc.identifier.other | 118966 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172524 | - |
dc.description.abstract | Zinc oxide nanoparticles (ZnO-np) are used in an increasing number of industrial products such as paint, coating and cosmetics, and in other biological applications. There have been many suggestions of a ZnO-np toxicity paradigm but the underlying molecular mechanisms about the toxicity of ZnO-np remain unclear. This study was done to determine the potential toxicity of ZnO-np and to assess the toxicity mechanism in normal skin cells. Synthesized ZnO-np generated reactive oxygen species (ROS), as determined by electron spin resonance. After uptake into cells, ZnO-np induced ROS in a concentration- and time-dependent manner. To demonstrate ZnO-np toxicity mechanism related to ROS, we detected abnormal autophagic vacuoles accumulation and mitochondria dysfunction after ZnO-np treatment. Furthermore mitochondria membrane potential and adenosine-5'-triphosphate (ATP) production are decreased for culture with ZnO-np. We conclude that ZnO-np leads to cell death through autophagic vacuole accumulation and mitochondria damage in normal skin cells via ROS induction. Accordingly, ZnO-np may cause toxicity and the results highlight and need for careful regulation of ZnO-np production and use. (C) 2013 Elsevier Ltd. All rights reserved. | - |
dc.language | 영어 | - |
dc.publisher | Elsevier BV | - |
dc.title | Zinc oxide nanoparticle induced autophagic cell death and mitochondrial damage via reactive oxygen species generation | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 조명행 | - |
dc.identifier.doi | 10.1016/j.tiv.2013.02.010 | - |
dc.citation.journaltitle | Toxicology in Vitro | - |
dc.identifier.wosid | 000318838000001 | - |
dc.identifier.scopusid | 2-s2.0-84875489407 | - |
dc.citation.endpage | 1195 | - |
dc.citation.number | 4 | - |
dc.citation.startpage | 1187 | - |
dc.citation.volume | 27 | - |
dc.identifier.sci | 000318838000001 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Cho, Myung-Haing | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | ZNO NANOPARTICLES | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.subject.keywordPlus | TOXICITY | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | RESPONSES | - |
dc.subject.keywordAuthor | Zinc oxide nanoparticles | - |
dc.subject.keywordAuthor | Cytotoxicity | - |
dc.subject.keywordAuthor | Autophagy | - |
dc.subject.keywordAuthor | Reactive oxygen species (ROS) | - |
dc.subject.keywordAuthor | Mitochondria damage | - |
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