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The simplest flowchart stating the mechanisms for organic xenobiotics-induced toxicity: Can it possibly be accepted as a central dogma for toxic mechanisms?
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Yeong-Chul | - |
dc.contributor.author | Lee, Sundong | - |
dc.contributor.author | Cho, Myung-Haing | - |
dc.date.accessioned | 2021-01-31T08:51:52Z | - |
dc.date.available | 2021-01-31T08:51:52Z | - |
dc.date.created | 2020-12-10 | - |
dc.date.issued | 2014-09 | - |
dc.identifier.citation | 한국독성학회지, Vol.30 No.3, pp.179-184 | - |
dc.identifier.issn | 1976-8257 | - |
dc.identifier.other | 118950 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172540 | - |
dc.description.abstract | Xenobiotics causing a variety of toxicity in biological systems could be classified as two types, inorganic and organic chemicals. It is estimated that the organic xenobiotics are responsible for approximately 80~90% of chemical-induced toxicity in human population. In the class for toxicology, we have encountered some difficulties in explaining the mechanisms of toxicity caused especially by organic chemicals. Here, a simple flowchart was introduced for explaining the mechanism of toxicity caused by organic xenobiotics, as the central dogma of molecular biology. This flowchart, referred to as a central dogma, was described based on a view of various aspects as follows: direct-acting chemicals vs. indirect-acting chemicals, cytochrome P450-dependent vs. cytochrome P450-independent biotransformation, reactive intermediates, reactivation, toxicokinetics vs. toxicodynamics, and reversibility vs. irreversibility. Thus, the primary objective of this flowchart is to help better understanding of the organic xenobiotics-induced toxic mechanisms, providing a major pathway for toxicity occurring in biological systems. | - |
dc.language | 영어 | - |
dc.publisher | 한국독성학회 | - |
dc.title | The simplest flowchart stating the mechanisms for organic xenobiotics-induced toxicity: Can it possibly be accepted as a central dogma for toxic mechanisms? | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 조명행 | - |
dc.identifier.doi | 10.5487/TR.2014.30.3.179 | - |
dc.citation.journaltitle | 한국독성학회지 | - |
dc.identifier.scopusid | 2-s2.0-84920535091 | - |
dc.citation.endpage | 184 | - |
dc.citation.number | 3 | - |
dc.citation.startpage | 179 | - |
dc.citation.volume | 30 | - |
dc.identifier.kciid | ART001913499 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Cho, Myung-Haing | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordAuthor | Biotransformation | - |
dc.subject.keywordAuthor | Cytochrome P450 | - |
dc.subject.keywordAuthor | Reactivation | - |
dc.subject.keywordAuthor | Reactive intermediates | - |
dc.subject.keywordAuthor | Reversibility vs. irreversibility | - |
dc.subject.keywordAuthor | Toxicokinetics vs. toxicodynamics | - |
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