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Synthesis of Hapten for Indirect Competitive Immunoassay for Measuring 3,5,6-trichloro-2-pyridinol
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Areumnuri | - |
dc.contributor.author | Kim, Joong-Young | - |
dc.contributor.author | Jeong, Sang-Hee | - |
dc.contributor.author | Cho, Myung-Haing | - |
dc.contributor.author | Park, Kyung-Hun | - |
dc.contributor.author | Cho, Namjun | - |
dc.contributor.author | Paik, Min Kyoung | - |
dc.date.accessioned | 2021-01-31T08:52:04Z | - |
dc.date.available | 2021-01-31T08:52:04Z | - |
dc.date.created | 2018-11-05 | - |
dc.date.issued | 2015-12 | - |
dc.identifier.citation | 한국환경농학회지, Vol.34 No.4, pp.345-349 | - |
dc.identifier.issn | 1225-3537 | - |
dc.identifier.other | 65870 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172544 | - |
dc.description.abstract | BACKGROUND: In this study, we have attempted to identify a urinary biomarker to assess chlorpyrifos exposure in farmers. The major metabolite and the excretion pathway of chlorpyrifos is 3,5,6-trichloro-2- pyridinol (TCP) in urine. Herein, we describe an adequate synthetic method for TCP hapten for measuring urinary TCP of farmers. METHODS AND RESULTS: First, TCP was prepared by spacer attachment through hydrolysis of thiophosphate ester from chlorpyrifos. After reaction with benzyl bromide, the TCP was transformed into 2,3,5-trichloro-6- benzyloxypyridine. Next, the chlorine in the 2nd position of the pyridyl ring was substituted into 3-mercaptopropanoic acid spacer arm. Finally, the phenyl group attached to the 6th position in pyridyl ring was removed for producing the targeted product, 3-(3,5-Dichloro-6-hydroxy-2-pyridyl) thiopropanoic acid. CONCLUSION: Henceforth, this TCP hapten would be used in developing immunoassay studies for the detection and quantitation of urinary TCP of farmers. | - |
dc.language | 영어 | - |
dc.publisher | 한국환경농학회 | - |
dc.title | Synthesis of Hapten for Indirect Competitive Immunoassay for Measuring 3,5,6-trichloro-2-pyridinol | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 조명행 | - |
dc.identifier.doi | 10.5338/KJEA.2015.34.4.38 | - |
dc.citation.journaltitle | 한국환경농학회지 | - |
dc.citation.endpage | 349 | - |
dc.citation.number | 4 | - |
dc.citation.startpage | 345 | - |
dc.citation.volume | 34 | - |
dc.identifier.kciid | ART002064218 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Cho, Myung-Haing | - |
dc.type.docType | Article | - |
dc.description.journalClass | 2 | - |
dc.subject.keywordAuthor | Chlorpyrifos | - |
dc.subject.keywordAuthor | Hapten | - |
dc.subject.keywordAuthor | TCP | - |
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