S-Space Graduate School of Convergence Science and Technology (융합과학기술대학원) Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과) Journal Papers (저널논문_분자의학 및 바이오제약학과)
Vitamin C and cancer chemoprevention: Reappraisal
- Lee, Ki Won; Lee, Hyong Joo; Surh, Young-Joon; Lee, Chang Yong
- Issue Date
- American Journal of Clinical Nutrition, Vol.78 No.6, pp.1074-1078
- Several studies have reported that even a moderate daily dose of supplementary vitamin C (200 mg) induces the formation of genotoxins from lipid hydroperoxides, thereby resulting in DNA damage and initiation of carcinogenesis. However, other reports questioned the experimental designs used and suggested that the chemopreventive effects of vitamin C may be linked to the inhibition of tumor promotion as well as to the blocking of tumor initiation. In this article, we discuss issues of contention and some controversies related to the potential chemopreventive effects of vitamin C in carcinogenesis.
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