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Signal transduction network leading to COX-2 induction: A road map in search of cancer chemopreventives

Cited 38 time in Web of Science Cited 38 time in Scopus
Authors
Surh, YoungJoon; Kundu, Joydeb Kumar
Issue Date
2005-01
Citation
Archives of Pharmacal Research, Vol.28 No.1, pp.1-15
Keywords
chemopreventioncyclooxygenase-2MAPKsPI3K-AktNF-kappa BAP-1signaling networkNSAIDsantiinflammatory phytochemicals
Abstract
Cancer is still a major global health concern even after an everlasting strive in conquering this dread disease. Emphasis is now given to chemoprevention to reduce the risk of cancer and also to improve the quality of life among cancer afflicted individuals. Recent progress in molecular biology of cancer has identified key components of the cellular signaling network, whose functional abnormality results in undesired alterations in cellular homeostasis. creating a cellular microenvironment that favors premalignant and malignant transformation. Multiple fines of, evidence suggest an elevated expression of cyclooxygenase-2 (COX-2) is causally linked to cancer. In response to oxidative/pro-inflammatory stimuli, turning on unusual signaling arrays mediated through diverse classes of kinases and transcription factors results in aberrant expression of COX-2. Population-based as well as laboratory studies have explored a broad spectrum of chemopreventive agents including selective COX-2 inhibitors and a wide variety of, anti-inflammatory phytochemicals, which have been shown to target cellular signaling molecules as underlying mechanisms of chemoprevention. Thus, unraveling signaling pathways regulating aberrant COX-2 expression and targeted blocking of one or more components or those signal cascades may be exploited in searching chemopreventive agents in the future.
ISSN
0253-6269
URI
https://hdl.handle.net/10371/172580
DOI
https://doi.org/10.1007/BF02975128
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Graduate School of Convergence Science and Technology (융합과학기술대학원)Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과)Journal Papers (저널논문_분자의학 및 바이오제약학과)
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