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Modulation by nitric oxide (NO) of capsaicin-induced calcium uptake into rat dorsal root ganglion neurons

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dc.contributor.authorPark, Young‐Ho-
dc.contributor.authorSurh, Young‐Joon-
dc.contributor.authorLee, Sang‐Sup-
dc.date.accessioned2021-01-31T09:22:53Z-
dc.date.available2021-01-31T09:22:53Z-
dc.date.issued1999-03-
dc.identifier.citationBiochemistry and Molecular Biology International, Vol.47 No.3, pp.435-442-
dc.identifier.issn1039-9712-
dc.identifier.other5163-
dc.identifier.urihttps://hdl.handle.net/10371/172622-
dc.description.abstractThe regulatory role of nitric oxide in capsaicin-induced Ca-45(2+) accumulation in dorsal root ganglion neuronal cultures was investigated. Capsaicin-activated calcium entry was subject to complicated tuning by NO-releasing agents sodium nitroprusside, spermine/NO complex and NO synthase inhibitor N-G-nitro-L-arginine methyl ester in concentration and stimulation protocol-dependent manner. In contrast, these agents failed to change depolarization-induced calcium influx. Tn experiments using dithiothreitol and 5,5-dithio-bis-2-nitrobenzoic acid this modulation was independent of the oxidizing action of NO. It is suggested that NO exerts a novel feedback modulatory effects on capsaicin-induced calcium entry into rat DRG neurons.-
dc.subjectcapsaicin-
dc.subjectnitric oxide-
dc.subjectcalcium influx-
dc.subjectdorsal root ganglion-
dc.titleModulation by nitric oxide (NO) of capsaicin-induced calcium uptake into rat dorsal root ganglion neurons-
dc.typeArticle-
dc.contributor.AlternativeAuthor서영준-
dc.identifier.doi10.1080/15216549900201463-
dc.citation.journaltitleBiochemistry and Molecular Biology International-
dc.identifier.scopusid2-s2.0-0032891311-
dc.citation.endpage442-
dc.citation.number3-
dc.citation.startpage435-
dc.citation.volume47-
dc.identifier.urlhttps://iubmb.onlinelibrary.wiley.com/doi/abs/10.1080/15216549900201463-
dc.identifier.rimsid5163-
dc.identifier.sci000079512300010-
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Graduate School of Convergence Science and Technology (융합과학기술대학원)Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과)Journal Papers (저널논문_분자의학 및 바이오제약학과)
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