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Genetic ablation of caspase-7 promotes solar-simulated light-induced mouse skin carcinogenesis: the involvement of keratin-17
DC Field | Value | Language |
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dc.contributor.author | Lee, Mee-Hyun | - |
dc.contributor.author | Lim, Do Young | - |
dc.contributor.author | Kim, Myoung Ok | - |
dc.contributor.author | Lee, Sung-Young | - |
dc.contributor.author | Shin, Seung Ho | - |
dc.contributor.author | Kim, Jae Young | - |
dc.contributor.author | Kim, Sung-Hyun | - |
dc.contributor.author | Kim, Dong Joon | - |
dc.contributor.author | Jung, Sung Keun | - |
dc.contributor.author | Yao, Ke | - |
dc.contributor.author | Kundu, Joydeb Kumar | - |
dc.contributor.author | Lee, Hye Suk | - |
dc.contributor.author | Lee, Cheol-Jung | - |
dc.contributor.author | Dickinson, Sally E. | - |
dc.contributor.author | Alberts, David | - |
dc.contributor.author | Bowden, G. Timothy | - |
dc.contributor.author | Stratton, Steven | - |
dc.contributor.author | Curiel, Clara | - |
dc.contributor.author | Einspahr, Janine | - |
dc.contributor.author | Bode, Ann M. | - |
dc.contributor.author | Surh, Young-Joon | - |
dc.contributor.author | Cho, Yong-Yeon | - |
dc.contributor.author | Dong, Zigang | - |
dc.date.accessioned | 2021-01-31T09:23:08Z | - |
dc.date.available | 2021-01-31T09:23:08Z | - |
dc.date.created | 2017-11-15 | - |
dc.date.issued | 2015-11 | - |
dc.identifier.citation | Carcinogenesis, Vol.36 No.11, pp.1372-1380 | - |
dc.identifier.issn | 0143-3334 | - |
dc.identifier.other | 793 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172626 | - |
dc.description.abstract | Solar ultraviolet irradiation is an environmental carcinogen that causes skin cancer. Caspase-7 is reportedly expressed at reduced levels in many cancers. The present study was designed to examine the role of caspase-7 in solar-simulated light (SSL)-induced skin cancer and to elucidate its underlying molecular mechanisms. Our study revealed that mice with genetic deficiency of caspase-7 are highly susceptible to SSL-induced skin carcinogenesis. Epidermal hyperplasia, tumor volume and the average number of tumors were significantly increased in caspase-7 knockout (KO) mice compared with SKH1 wild-type mice irradiated with SSL. The expression of cell proliferation markers, such as survivin and Ki67, was elevated in SSL-irradiated skin of caspase-7 KO mice compared with those observed in SSL-exposed wild-type SKH1 mouse skin. Moreover, SSL-induced apoptosis was abolished in skin from caspase-7 KO mice. Two-dimensional gel electrophoresis, followed by matrix-assisted laser desorption/ ionization-time-of-flight analysis of skin tissue lysates from SSL-irradiated SKH1 wild-type and caspase-7 KO mice revealed an aberrant induction of keratin-17 in caspase-7 KO mice. Immunohistochemical analysis of skin tumors also showed an increase of keratin-17 expression in caspase-7 KO mice compared with SKH1 wild-type mice. The expression of keratin-17 was also elevated in SSL-irradiated caspase-7 KO keratinocytes as well as in human basal cell carcinomas. The in vitro caspase activity assay showed keratin-17 as a substrate of caspase-7, but not caspase-3. Overall, our study demonstrates that genetic loss of caspase-7 promotes SSL-induced skin carcinogenesis by blocking caspase-7-mediated cleavage of keratin-17. | - |
dc.language | 영어 | - |
dc.publisher | Oxford University Press | - |
dc.title | Genetic ablation of caspase-7 promotes solar-simulated light-induced mouse skin carcinogenesis: the involvement of keratin-17 | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.identifier.doi | 10.1093/carcin/bgv110 | - |
dc.citation.journaltitle | Carcinogenesis | - |
dc.identifier.wosid | 000366386800014 | - |
dc.identifier.scopusid | 2-s2.0-85006271239 | - |
dc.citation.endpage | 1380 | - |
dc.citation.number | 11 | - |
dc.citation.startpage | 1372 | - |
dc.citation.volume | 36 | - |
dc.identifier.sci | 000366386800014 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Surh, Young-Joon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | UV-INDUCED APOPTOSIS | - |
dc.subject.keywordPlus | MOLECULAR-MECHANISMS | - |
dc.subject.keywordPlus | HEPATOCELLULAR-CARCINOMA | - |
dc.subject.keywordPlus | ULTRAVIOLET-RADIATION | - |
dc.subject.keywordPlus | PROTEOMIC ANALYSIS | - |
dc.subject.keywordPlus | PHOTOCARCINOGENESIS | - |
dc.subject.keywordPlus | STRATEGIES | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | LISTS | - |
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