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Resveratrol Inhibits IL-6-Induced Transcriptional Activity of AR and STAT3 in Human Prostate Cancer LNCaP-FGC Cells
DC Field | Value | Language |
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dc.contributor.author | Lee, Mee-Hyun | - |
dc.contributor.author | Kundu, Joydeb Kumar | - |
dc.contributor.author | Keum, Young-Sam | - |
dc.contributor.author | Cho, Yong-Yeon | - |
dc.contributor.author | Surh, Young-Joon | - |
dc.contributor.author | Choi, Bu Young | - |
dc.date.accessioned | 2021-01-31T09:24:06Z | - |
dc.date.available | 2021-01-31T09:24:06Z | - |
dc.date.created | 2017-11-15 | - |
dc.date.issued | 2014-09 | - |
dc.identifier.citation | Biomolecules & Therapeutics, Vol.22 No.5, pp.426-430 | - |
dc.identifier.issn | 1976-9148 | - |
dc.identifier.other | 1220 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172642 | - |
dc.description.abstract | Prostate cancer is the most frequently diagnosed cancer. Although prostate tumors respond to androgen ablation therapy at an early stage, they often acquire the potential of androgen-independent growth. Elevated transcriptional activity of androgen receptor (AR) and/or signal transducer and activator of transcription-3 (STAT3) contributes to the proliferation of prostate cancer cells. In the present study, we examined the effect of resveratrol, a phytoalexin present in grapes, on the reporter gene activity of AR and STAT3 in human prostate cancer (LNCaP-FGC) cells stimulated with interleukin-6 (IL-6) and/or dihydrotestosterone (DHT). Our study revealed that resveratrol suppressed the growth of LNCaP-FGC cells in a time- and concentration-dependent manner. Whereas the AR transcriptional activity was induced by treatment with either IL-6 or DHT, the STAT3 transcriptional activity was induced only by treatment with IL-6 but not with DHT. Resveratrol significantly attenuated IL-6-induced STAT3 transcriptional activity, and DHT- or IL-6-induced AR transcriptional activity. Treatment of cells with DHT plus IL-6 significantly increased the AR transcriptional activity as compared to DHT or IL-6 treatment alone and resveratrol markedly diminished DHT plus IL-6-induced AR transcriptional activity. Furthermore, the production of prostate-specific antigen (PSA) was decreased by resveratrol in the DHT-, IL-6- or DHT plus IL-6-treated LNCaP-FGC cells. Taken together, the inhibitory effects of resveratrol on IL-6- and/or DHT-induced AR transcriptional activity in LNCaP prostate cancer cells are partly mediated through the suppression of STAT3 reporter gene activity, suggesting that resveratrol may be a promising therapeutic choice for the treatment of prostate cancer. | - |
dc.language | 영어 | - |
dc.publisher | 한국응용약물학회 | - |
dc.title | Resveratrol Inhibits IL-6-Induced Transcriptional Activity of AR and STAT3 in Human Prostate Cancer LNCaP-FGC Cells | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.identifier.doi | 10.4062/biomolther.2014.061 | - |
dc.citation.journaltitle | Biomolecules & Therapeutics | - |
dc.identifier.wosid | 000342856200008 | - |
dc.identifier.scopusid | 2-s2.0-84908018839 | - |
dc.citation.endpage | 430 | - |
dc.citation.number | 5 | - |
dc.citation.startpage | 426 | - |
dc.citation.volume | 22 | - |
dc.identifier.sci | 000342856200008 | - |
dc.identifier.kciid | ART001915282 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Surh, Young-Joon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ANDROGEN RECEPTOR | - |
dc.subject.keywordPlus | MOLECULAR-MECHANISMS | - |
dc.subject.keywordPlus | CHEMOPREVENTION | - |
dc.subject.keywordPlus | PIM1 | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordAuthor | Resveratrol | - |
dc.subject.keywordAuthor | AR transcriptional activity | - |
dc.subject.keywordAuthor | STAT3 transcriptional activity | - |
dc.subject.keywordAuthor | Prostate cancer | - |
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