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Myc-nick promotes efferocytosis through M2 macrophage polarization during resolution of inflammation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Zhong, Xiancai | - |
dc.contributor.author | Lee, Ha-Na | - |
dc.contributor.author | Kim, Seung Hyeon | - |
dc.contributor.author | Park, Sin-Aye | - |
dc.contributor.author | Kim, Wonki | - |
dc.contributor.author | Cha, Young-Nam | - |
dc.contributor.author | Surh, Young-Joon | - |
dc.date.accessioned | 2021-01-31T09:27:51Z | - |
dc.date.available | 2021-01-31T09:27:51Z | - |
dc.date.created | 2019-06-17 | - |
dc.date.issued | 2018-10 | - |
dc.identifier.citation | FASEB Journal, Vol.32 No.10, pp.5312-5325 | - |
dc.identifier.issn | 0892-6638 | - |
dc.identifier.other | 75811 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172699 | - |
dc.description.abstract | A key event required for effective resolution of inflammation is efferocytosis, which is defined as phagocytic removal of apoptotic cells mostly by macrophages acquiring an alternatively activated phenotype (M2). c-Myc has been reported to play a role in alternative activation of human macrophages and is proposed as one of the M2 macrophage markers. We found that M2-like peritoneal macrophages from zymosan A-treated mice exhibited a marked accumulation of Myc-nick, a truncated protein generated by a Calpain-mediated proteolytic cleavage of full-length c-Myc. Further, ectopic expression of Myc-nick in murine bone marrow-derived macrophages promoted the M2 polarization and, consequently, enhanced their efferocytic capability. Notably, Myc-nick-induced efferocytosis was found to be tightly associated with -tubulin acetylation by K acetyltransferase 2a (Kat2a/Gcn5) activity. These findings suggest Myc-nick as a novel proresolving mediator that has a fundamental function in maintaining homeostasis under inflammatory conditions.Zhong, X., Lee, H.-N., Kim, S. H., Park, S.-A., Kim, W., Cha, Y.-N., Surh, Y.-J. Myc-nick promotes efferocytosis through M2 macrophage polarization during resolution of inflammation. | - |
dc.language | 영어 | - |
dc.publisher | Federation of American Societies for Experimental Biology | - |
dc.title | Myc-nick promotes efferocytosis through M2 macrophage polarization during resolution of inflammation | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.identifier.doi | 10.1096/fj.201800223R | - |
dc.citation.journaltitle | FASEB Journal | - |
dc.identifier.wosid | 000447972500010 | - |
dc.identifier.scopusid | 2-s2.0-85054066359 | - |
dc.citation.endpage | 5325 | - |
dc.citation.number | 10 | - |
dc.citation.startpage | 5312 | - |
dc.citation.volume | 32 | - |
dc.identifier.sci | 000447972500010 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Surh, Young-Joon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | APOPTOTIC CELLS | - |
dc.subject.keywordPlus | PHOSPHATIDYLSERINE RECEPTOR | - |
dc.subject.keywordPlus | TUBULIN ACETYLATION | - |
dc.subject.keywordPlus | DEAD CELLS | - |
dc.subject.keywordPlus | C-MYC | - |
dc.subject.keywordPlus | ENGULFMENT | - |
dc.subject.keywordPlus | PHAGOCYTOSIS | - |
dc.subject.keywordPlus | CLEARANCE | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | LYSOSOMES | - |
dc.subject.keywordAuthor | c-Myc | - |
dc.subject.keywordAuthor | phagocytosis | - |
dc.subject.keywordAuthor | peritonitis | - |
dc.subject.keywordAuthor | tubulin acetylation | - |
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