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Heat-processed neoginseng, KG-135, down-regulates G1 Cyclin-dependent kinase through the proteasome-mediated pathway in HeLa cells
DC Field | Value | Language |
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dc.contributor.author | Lee, Won-Hee | - |
dc.contributor.author | Choi, Joon-Seok | - |
dc.contributor.author | Kim, Hyun Young | - |
dc.contributor.author | Park, Jeong-Hill | - |
dc.contributor.author | Lee, Seung-Ki | - |
dc.contributor.author | Surh, Young-Joon | - |
dc.date.accessioned | 2021-01-31T09:29:31Z | - |
dc.date.available | 2021-01-31T09:29:31Z | - |
dc.date.created | 2017-11-15 | - |
dc.date.issued | 2009-02 | - |
dc.identifier.citation | Oncology Reports, Vol.21 No.2, pp.467-474 | - |
dc.identifier.issn | 1021-335X | - |
dc.identifier.other | 2968 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172725 | - |
dc.description.abstract | High temperature heat treatment of ginseng (Panax ginseng, C.A. Meyer) generates KG-135 (heat-processed neoginseng) which contains a mixture of three major ginseng saponins, ginsenosides Rk1, Rg3 and Rg5. Ginsenosides, particularly of the diol-type including Rk1, Rg3 and Rg5, have been shown to induce cell growth arrest in various cell types of human cancer. Herein, we report that KG-135 is able to arrest the cell cycle in human cervix adenocarcinoma HeLa cells. KG-135 arrests cells at the G1 phase of the cell cycle with an IC(50) value of 69 mu g/ml. The G1 phase arrest is associated with down-regulation of Cyclin D1/Cdk4 and Cyclin B1/Cdc2 activities in cells after treatment with KG-135. Furthermore, down-regulation of G1 Cyclin-dependent kinase activities is kinetically well related to the decreased intracellular protein levels of these kinases. In addition, the decrease in the levels of Cyclin D1/Cdk4 and Cyclin B1, but not of Cdc2, is similarly prevented by co-treatment of cells with MG-132, a potent proteasome inhibitor. Thus, the KG-135-induced arrest of the cell cycle at G1 phase in HeLa cells represents a novel mechanism that involves proteasome-mediated degradation of the Cyclins (Cyclin D1 and B 1) and Cdk4 proteins. | - |
dc.language | 영어 | - |
dc.publisher | Demetrios A. Spandidos Ed. & Pub. | - |
dc.title | Heat-processed neoginseng, KG-135, down-regulates G1 Cyclin-dependent kinase through the proteasome-mediated pathway in HeLa cells | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.identifier.doi | 10.3892/or_00000246 | - |
dc.citation.journaltitle | Oncology Reports | - |
dc.identifier.wosid | 000262679300029 | - |
dc.identifier.scopusid | 2-s2.0-62849092336 | - |
dc.citation.endpage | 474 | - |
dc.citation.number | 2 | - |
dc.citation.startpage | 467 | - |
dc.citation.volume | 21 | - |
dc.identifier.sci | 000262679300029 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Park, Jeong-Hill | - |
dc.contributor.affiliatedAuthor | Lee, Seung-Ki | - |
dc.contributor.affiliatedAuthor | Surh, Young-Joon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ELEVATES PROTEIN-LEVELS | - |
dc.subject.keywordPlus | BREAST-CANCER CELLS | - |
dc.subject.keywordPlus | SK-HEP-1 CELLS | - |
dc.subject.keywordPlus | PANAX-GINSENG | - |
dc.subject.keywordPlus | DAMMARANE GLYCOSIDES | - |
dc.subject.keywordPlus | MAMMALIAN-CELLS | - |
dc.subject.keywordPlus | CDK2 ACTIVITY | - |
dc.subject.keywordPlus | TUMOR-CELLS | - |
dc.subject.keywordPlus | MITOMYCIN-C | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordAuthor | ginsenosides | - |
dc.subject.keywordAuthor | G1 phase | - |
dc.subject.keywordAuthor | Cyclin B1/Cdc2 | - |
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