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[6]-Gingerol prevents UVB-induced ROS production and COX-2 expression in vitro and in vivo

Cited 144 time in Web of Science Cited 170 time in Scopus
Issue Date
2007
Citation
Free Radical Research, Vol.41 No.5, pp.603-614
Keywords
UVB[6]-gingerolROScyclooxygenase-2NF-kappa Bcaspase
Abstract
[6]-Gingerol, a naturally occurring plant phenol, is one of the major components of fresh ginger (Zingiber officinale Roscoe, Zingiberaceae) and has diverse pharmacologic effects. Here, we describe its novel anti-oxidant, anti-apoptotic, and anti-inflammatory activities in vitro and in vivo. In vitro, pre-treatment with [6]-gingerol reduced UVB-induced intracellular reactive oxygen species levels, activation of caspase-3, -8, -9, and Fas expression. It also reduced UVB-induced expression and transactivation of COX-2. Translocation of NF-kappa B from cytosol to nucleus in HaCaT cells was inhibited by [6]-gingerol via suppression of I kappa B alpha phosphorylation (ser-32). Examination by EMSAs and immunohistochemistry showed that topical application of [6]-gingerol (30 mM) prior to UVB irradiation (5 kJ/m(2)) of hairless mice, also inhibited the induction of COX-2 mRNA and protein, as well as NF-kappa B translocation. These results suggest that [6]-gingerol could be an effective therapeutic agent providing protection against UVB-induced skin disorders.
ISSN
1071-5762
URI
https://hdl.handle.net/10371/172748
DOI
https://doi.org/10.1080/10715760701209896
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Graduate School of Convergence Science and Technology (융합과학기술대학원)Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과)Journal Papers (저널논문_분자의학 및 바이오제약학과)
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