Publications
Detailed Information
[6]-Gingerol prevents UVB-induced ROS production and COX-2 expression in vitro and in vivo
Cited 159 time in
Web of Science
Cited 192 time in Scopus
- Authors
- Issue Date
- 2007
- Publisher
- Taylor & Francis
- Citation
- Free Radical Research, Vol.41 No.5, pp.603-614
- Abstract
- [6]-Gingerol, a naturally occurring plant phenol, is one of the major components of fresh ginger (Zingiber officinale Roscoe, Zingiberaceae) and has diverse pharmacologic effects. Here, we describe its novel anti-oxidant, anti-apoptotic, and anti-inflammatory activities in vitro and in vivo. In vitro, pre-treatment with [6]-gingerol reduced UVB-induced intracellular reactive oxygen species levels, activation of caspase-3, -8, -9, and Fas expression. It also reduced UVB-induced expression and transactivation of COX-2. Translocation of NF-kappa B from cytosol to nucleus in HaCaT cells was inhibited by [6]-gingerol via suppression of I kappa B alpha phosphorylation (ser-32). Examination by EMSAs and immunohistochemistry showed that topical application of [6]-gingerol (30 mM) prior to UVB irradiation (5 kJ/m(2)) of hairless mice, also inhibited the induction of COX-2 mRNA and protein, as well as NF-kappa B translocation. These results suggest that [6]-gingerol could be an effective therapeutic agent providing protection against UVB-induced skin disorders.
- ISSN
- 1071-5762
- Files in This Item:
- There are no files associated with this item.
- Appears in Collections:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.