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Triphlorethol-A induces heme oxygenase-1 via activation of ERK and NF-E2 related factor 2 transcription factor
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Kang, Kyoung Ah | - |
| dc.contributor.author | Lee, Kyoung Hwa | - |
| dc.contributor.author | Park, Jae Woo | - |
| dc.contributor.author | Lee, Nam Ho | - |
| dc.contributor.author | Na, Hye Kyung | - |
| dc.contributor.author | Surh, Young Joon | - |
| dc.contributor.author | You, Ho Jin | - |
| dc.contributor.author | Chung, Myung Hee | - |
| dc.contributor.author | Hyun, Jin Won | - |
| dc.date.accessioned | 2021-01-31T10:15:20Z | - |
| dc.date.available | 2021-01-31T10:15:20Z | - |
| dc.date.created | 2017-11-15 | - |
| dc.date.issued | 2007-05 | - |
| dc.identifier.citation | FEBS Letters, Vol.581 No.10, pp.2000-2008 | - |
| dc.identifier.issn | 0014-5793 | - |
| dc.identifier.other | 3460 | - |
| dc.identifier.uri | https://hdl.handle.net/10371/172762 | - |
| dc.description.abstract | Triphlorethol-A, phlorotannin found in Ecklonia cava, induced heine oxygenase-1 (HO-1) expression at mRNA and protein levels, leading to increased HO-I activity. Transcription factor NF-E2 related factor 2 (Nrf2) regulates antioxidant response element (ARE) of phase 2 detoxifying and antioxidant enzymes. Triphlorethol-A increased nuclear translocation, ARE binding, and transcriptional activity of Nrf2. Triphlorethol-A exhibited activation of ERK and U0126, inhibitor of ERK kinase, suppressed triphlorethol-A induced activation of Nrf2, finally decreased HO-1 protein level. Taken together, these data suggest that triphlorethol-A augments cellular antioxidant defense capacity through induction of HO-I via ERK-Nrf2-ARE signaling pathway, thereby protecting cells from oxidative stress. (C) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. | - |
| dc.language | 영어 | - |
| dc.publisher | Elsevier BV | - |
| dc.title | Triphlorethol-A induces heme oxygenase-1 via activation of ERK and NF-E2 related factor 2 transcription factor | - |
| dc.type | Article | - |
| dc.contributor.AlternativeAuthor | 서영준 | - |
| dc.identifier.doi | 10.1016/j.febslet.2007.04.022 | - |
| dc.citation.journaltitle | FEBS Letters | - |
| dc.identifier.wosid | 000246728700012 | - |
| dc.identifier.scopusid | 2-s2.0-34247558595 | - |
| dc.citation.endpage | 2008 | - |
| dc.citation.number | 10 | - |
| dc.citation.startpage | 2000 | - |
| dc.citation.volume | 581 | - |
| dc.identifier.sci | 000246728700012 | - |
| dc.description.isOpenAccess | N | - |
| dc.contributor.affiliatedAuthor | Surh, Young Joon | - |
| dc.contributor.affiliatedAuthor | Chung, Myung Hee | - |
| dc.type.docType | Article | - |
| dc.description.journalClass | 1 | - |
| dc.subject.keywordPlus | ANTIOXIDANT-RESPONSIVE ELEMENT | - |
| dc.subject.keywordPlus | ECKLONIA-KUROME OKAMURA | - |
| dc.subject.keywordPlus | INDUCED CELL-DAMAGE | - |
| dc.subject.keywordPlus | ANTI-PLASMIN INHIBITOR | - |
| dc.subject.keywordPlus | OXIDATIVE STRESS | - |
| dc.subject.keywordPlus | GENE-EXPRESSION | - |
| dc.subject.keywordPlus | ENDOTHELIAL-CELLS | - |
| dc.subject.keywordPlus | CHEMOPREVENTIVE AGENTS | - |
| dc.subject.keywordPlus | NF-E2-RELATED FACTOR-2 | - |
| dc.subject.keywordPlus | REGULATORY MECHANISMS | - |
| dc.subject.keywordAuthor | triphlorethol-A | - |
| dc.subject.keywordAuthor | heme oxygenase-1 | - |
| dc.subject.keywordAuthor | NF-E2 related factor 2 | - |
| dc.subject.keywordAuthor | antioxidant response element | - |
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