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Triphlorethol-A induces heme oxygenase-1 via activation of ERK and NF-E2 related factor 2 transcription factor

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dc.contributor.authorKang, Kyoung Ah-
dc.contributor.authorLee, Kyoung Hwa-
dc.contributor.authorPark, Jae Woo-
dc.contributor.authorLee, Nam Ho-
dc.contributor.authorNa, Hye Kyung-
dc.contributor.authorSurh, Young-Joon-
dc.contributor.authorYou, Ho Jin-
dc.contributor.authorChung, Myung Hee-
dc.contributor.authorHyun, Jin Won-
dc.date.accessioned2021-01-31T10:15:20Z-
dc.date.available2021-01-31T10:15:20Z-
dc.date.issued2007-05-
dc.identifier.citationFEBS Letters, Vol.581 No.10, pp.2000-2008-
dc.identifier.issn0014-5793-
dc.identifier.other3460-
dc.identifier.urihttps://hdl.handle.net/10371/172762-
dc.description.abstractTriphlorethol-A, phlorotannin found in Ecklonia cava, induced heine oxygenase-1 (HO-1) expression at mRNA and protein levels, leading to increased HO-I activity. Transcription factor NF-E2 related factor 2 (Nrf2) regulates antioxidant response element (ARE) of phase 2 detoxifying and antioxidant enzymes. Triphlorethol-A increased nuclear translocation, ARE binding, and transcriptional activity of Nrf2. Triphlorethol-A exhibited activation of ERK and U0126, inhibitor of ERK kinase, suppressed triphlorethol-A induced activation of Nrf2, finally decreased HO-1 protein level. Taken together, these data suggest that triphlorethol-A augments cellular antioxidant defense capacity through induction of HO-I via ERK-Nrf2-ARE signaling pathway, thereby protecting cells from oxidative stress. (C) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.-
dc.subjecttriphlorethol-A-
dc.subjectheme oxygenase-1-
dc.subjectNF-E2 related factor 2-
dc.subjectantioxidant response element-
dc.titleTriphlorethol-A induces heme oxygenase-1 via activation of ERK and NF-E2 related factor 2 transcription factor-
dc.typeArticle-
dc.contributor.AlternativeAuthor서영준-
dc.identifier.doi10.1016/j.febslet.2007.04.022-
dc.citation.journaltitleFEBS Letters-
dc.identifier.scopusid2-s2.0-34247558595-
dc.citation.endpage2008-
dc.citation.number10-
dc.citation.startpage2000-
dc.citation.volume581-
dc.identifier.urlhttps://febs.onlinelibrary.wiley.com/doi/full/10.1016/j.febslet.2007.04.022-
dc.identifier.rimsid3460-
dc.identifier.sci000246728700012-
dc.contributor.affiliatedAuthorSurh, Young-Joon-
Appears in Collections:
Graduate School of Convergence Science and Technology (융합과학기술대학원)Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과)Journal Papers (저널논문_분자의학 및 바이오제약학과)
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