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Thymoquinone inhibits phorbol ester-induced activation of NF-kappa B and expression of COX-2, and induces expression of cytoprotective enzymes in mouse skin in vivo
DC Field | Value | Language |
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dc.contributor.author | Kundu, Joydeb Kumar | - |
dc.contributor.author | Liu, Lijia | - |
dc.contributor.author | Shin, Jun-Wan | - |
dc.contributor.author | Surh, Young-Joon | - |
dc.date.accessioned | 2021-01-31T10:15:40Z | - |
dc.date.available | 2021-01-31T10:15:40Z | - |
dc.date.created | 2017-11-15 | - |
dc.date.issued | 2013-09 | - |
dc.identifier.citation | Biochemical and Biophysical Research Communications, Vol.438 No.4, pp.721-727 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.other | 1561 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172766 | - |
dc.description.abstract | Thymoquinone (TQ), the active ingredient of Nigella sativa, has been reported to possess anti-inflammatory and chemopreventive properties. The present study was aimed at elucidating the molecular mechanisms of anti-inflammatory and antioxidative activities of thymoquinone in mouse skin. Pretreatment of female HR-1 hairless mouse skin with TQ attenuated 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced expression of cyclookygenase-2 (COX-2). TQ diminished nuclear translocation and the DNA binding of nuclear factor-kappaB (NF-kappa B) via the blockade of phosphorylation and subsequent degradation of I kappa B alpha. in TPA-treated mouse skin. Pretreatment with TQ attenuated the phosphorylation of Akt, c-Jun-N-terminal kinase and p38 mitogen-activated protein kinase, but not that of extracellular signal-regulated kinase-1/2. Moreover, topical application of TQ induced the expression of heme oxygenase-1, NAD(P)H-quinoneoxidoreductase-1, glutathione-S-transferase and glutamate cysteine ligase in mouse skin. Taken together, the inhibitory effects of TQ on TPA-induced COX-2 expression and NF-kappa B activation, and its ability to induce the expression of cytoprotective proteins provide a mechanistic basis of anti-inflammatory and antioxidative effects of TQ in hairless mouse skin. (C) 2013 Elsevier Inc. All rights reserved. | - |
dc.language | 영어 | - |
dc.publisher | Academic Press | - |
dc.title | Thymoquinone inhibits phorbol ester-induced activation of NF-kappa B and expression of COX-2, and induces expression of cytoprotective enzymes in mouse skin in vivo | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.identifier.doi | 10.1016/j.bbrc.2013.07.110 | - |
dc.citation.journaltitle | Biochemical and Biophysical Research Communications | - |
dc.identifier.wosid | 000324454800025 | - |
dc.identifier.scopusid | 2-s2.0-84883294242 | - |
dc.citation.endpage | 727 | - |
dc.citation.number | 4 | - |
dc.citation.startpage | 721 | - |
dc.citation.volume | 438 | - |
dc.identifier.sci | 000324454800025 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Surh, Young-Joon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | SIGNAL-TRANSDUCTION PATHWAYS | - |
dc.subject.keywordPlus | P38 MAP KINASE | - |
dc.subject.keywordPlus | NIGELLA-SATIVA | - |
dc.subject.keywordPlus | CYCLOOXYGENASE-2 EXPRESSION | - |
dc.subject.keywordPlus | OXIDOREDUCTASE-1 DEFICIENCY | - |
dc.subject.keywordPlus | TRANSCRIPTIONAL REGULATION | - |
dc.subject.keywordPlus | ANTITUMOR-ACTIVITY | - |
dc.subject.keywordPlus | PANCREATIC-CANCER | - |
dc.subject.keywordPlus | PRIME TARGETS | - |
dc.subject.keywordPlus | COLON-CANCER | - |
dc.subject.keywordAuthor | Thymoquinone | - |
dc.subject.keywordAuthor | Cyclooxygenase-2 | - |
dc.subject.keywordAuthor | Nuclear factor-kappaB | - |
dc.subject.keywordAuthor | Cytoprotective enzymes | - |
dc.subject.keywordAuthor | Mouse skin | - |
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