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Thymoquinone inhibits phorbol ester-induced activation of NF-kappa B and expression of COX-2, and induces expression of cytoprotective enzymes in mouse skin in vivo

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dc.contributor.authorKundu, Joydeb Kumar-
dc.contributor.authorLiu, Lijia-
dc.contributor.authorShin, Jun-Wan-
dc.contributor.authorSurh, Young-Joon-
dc.date.accessioned2021-01-31T10:15:40Z-
dc.date.available2021-01-31T10:15:40Z-
dc.date.issued2013-09-
dc.identifier.citationBiochemical and Biophysical Research Communications, Vol.438 No.4, pp.721-727-
dc.identifier.issn0006-291X-
dc.identifier.other1561-
dc.identifier.urihttps://hdl.handle.net/10371/172766-
dc.description.abstractThymoquinone (TQ), the active ingredient of Nigella sativa, has been reported to possess anti-inflammatory and chemopreventive properties. The present study was aimed at elucidating the molecular mechanisms of anti-inflammatory and antioxidative activities of thymoquinone in mouse skin. Pretreatment of female HR-1 hairless mouse skin with TQ attenuated 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced expression of cyclookygenase-2 (COX-2). TQ diminished nuclear translocation and the DNA binding of nuclear factor-kappaB (NF-kappa B) via the blockade of phosphorylation and subsequent degradation of I kappa B alpha. in TPA-treated mouse skin. Pretreatment with TQ attenuated the phosphorylation of Akt, c-Jun-N-terminal kinase and p38 mitogen-activated protein kinase, but not that of extracellular signal-regulated kinase-1/2. Moreover, topical application of TQ induced the expression of heme oxygenase-1, NAD(P)H-quinoneoxidoreductase-1, glutathione-S-transferase and glutamate cysteine ligase in mouse skin. Taken together, the inhibitory effects of TQ on TPA-induced COX-2 expression and NF-kappa B activation, and its ability to induce the expression of cytoprotective proteins provide a mechanistic basis of anti-inflammatory and antioxidative effects of TQ in hairless mouse skin. (C) 2013 Elsevier Inc. All rights reserved.-
dc.subjectThymoquinone-
dc.subjectCyclooxygenase-2-
dc.subjectNuclear factor-kappaB-
dc.subjectCytoprotective enzymes-
dc.subjectMouse skin-
dc.titleThymoquinone inhibits phorbol ester-induced activation of NF-kappa B and expression of COX-2, and induces expression of cytoprotective enzymes in mouse skin in vivo-
dc.typeArticle-
dc.contributor.AlternativeAuthor서영준-
dc.identifier.doi10.1016/j.bbrc.2013.07.110-
dc.citation.journaltitleBiochemical and Biophysical Research Communications-
dc.identifier.scopusid2-s2.0-84883294242-
dc.citation.endpage727-
dc.citation.number4-
dc.citation.startpage721-
dc.citation.volume438-
dc.identifier.rimsid1561-
dc.identifier.sci000324454800025-
dc.contributor.affiliatedAuthorSurh, Young-Joon-
Appears in Collections:
Graduate School of Convergence Science and Technology (융합과학기술대학원)Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과)Journal Papers (저널논문_분자의학 및 바이오제약학과)
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