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Cancer chemopreventive and therapeutic potential of resveratrol: Mechanistic perspectives
DC Field | Value | Language |
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dc.contributor.author | Kundu, Joydeb Kumar | - |
dc.contributor.author | Surh, Young-Joon | - |
dc.date.accessioned | 2021-01-31T10:16:40Z | - |
dc.date.available | 2021-01-31T10:16:40Z | - |
dc.date.created | 2017-11-15 | - |
dc.date.issued | 2008-10 | - |
dc.identifier.citation | Cancer Letters, Vol.269 No.2, pp.243-261 | - |
dc.identifier.issn | 0304-3835 | - |
dc.identifier.other | 3076 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172779 | - |
dc.description.abstract | A plant kingdom is considered as a gold mine for the discovery of many biologically active substances with therapeutic values. Resveratrol (3,5,4'-trihydroxystilbene), a naturally occurring polyphenol, exhibits pleiotropic health beneficial effects including anti-oxidant, anti-inflammatory, cardioprotective and anti-tumor activities. Currently, numerous preclinical findings suggest resveratrol as a promising nature's arsenal for cancer prevention and treatment. A remarkable progress in dissecting the molecular mechanisms underlying anti-cancer properties of resveratrol has been achieved in the past decade. As a potential anti-cancer agent, resveratrol has been shown to inhibit or retard the growth of various cancer cells in culture and implanted tumors in vivo. The compound significantly inhibits experimental tumorigenesis in a wide range of animal models. Resveratrol targets many components of intracellular signaling pathways including pro-inflammatory mediators, regulators of cell survival and apoptosis, and tumor angiogenic and metastatic switches by modulating a distinct set of upstream kinases, transcription factors and their regulators. This review summarizes the diverse molecular targets of resveratrol with a special focus on those involved in fine-tuning of orchestrated intracellular signal transduction. (C) 2008 Elsevier Ireland Ltd. All rights reserved. | - |
dc.language | 영어 | - |
dc.publisher | Elsevier BV | - |
dc.title | Cancer chemopreventive and therapeutic potential of resveratrol: Mechanistic perspectives | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.identifier.doi | 10.1016/j.canlet.2008.03.057 | - |
dc.citation.journaltitle | Cancer Letters | - |
dc.identifier.wosid | 000260143500006 | - |
dc.identifier.scopusid | 2-s2.0-51349132313 | - |
dc.citation.endpage | 261 | - |
dc.citation.number | 2 | - |
dc.citation.startpage | 243 | - |
dc.citation.volume | 269 | - |
dc.identifier.sci | 000260143500006 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Surh, Young-Joon | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | HUMAN BREAST-CANCER | - |
dc.subject.keywordPlus | MAMMARY EPITHELIAL-CELLS | - |
dc.subject.keywordPlus | INHIBITS PHORBOL ESTER | - |
dc.subject.keywordPlus | NITRIC-OXIDE SYNTHASE | - |
dc.subject.keywordPlus | CARCINOMA A431 CELLS | - |
dc.subject.keywordPlus | S-PHASE ARREST | - |
dc.subject.keywordPlus | ENDOTHELIAL GROWTH-FACTOR | - |
dc.subject.keywordPlus | MOUSE SKIN TUMORIGENESIS | - |
dc.subject.keywordPlus | DEXTRAN SODIUM-SULFATE | - |
dc.subject.keywordAuthor | Resveratrol | - |
dc.subject.keywordAuthor | Chemoprevention | - |
dc.subject.keywordAuthor | Signal transduction | - |
dc.subject.keywordAuthor | Phytochemicals | - |
dc.subject.keywordAuthor | Anti-carcinogenesis | - |
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