S-Space Graduate School of Convergence Science and Technology (융합과학기술대학원) Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과) Journal Papers (저널논문_분자의학 및 바이오제약학과)
Nrf2, an Essential Component of Cellular Stress Response, as a Potential Target of Hormetic Phytochemicals
- Surh, Young-Joon
- Issue Date
- Journal of Food and Drug Analysis, Vol.20, pp.217-219
- Living organisms have evolved ubiquitous mechanisms to manage a vast multitude of stressors and noxious conditions. Although Nrf2 mainly plays a major role in cellular antioxidant defence, results from recent studies have highlighted its ubiquitous roles in cellular cytoprotection including anti-inflammatory function. As oxidative stress and inflammatory tissue damage are two major culprits in the pathogenesis of the majority of malignancies and other disorders, Nrf2 is recognized as a potential preventive target. Some chemoprotective and chemopreventive phytochemicals are capable of activating Nrf2 signaling, thereby fortifying cellular defence capacity.
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