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Nrf2, an Essential Component of Cellular Stress Response, as a Potential Target of Hormetic Phytochemicals

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Authors
Surh, Young-Joon
Issue Date
2012-04
Citation
Journal of Food and Drug Analysis, Vol.20, pp.217-219
Keywords
Nrf2Keap1Stress response
Abstract
Living organisms have evolved ubiquitous mechanisms to manage a vast multitude of stressors and noxious conditions. Although Nrf2 mainly plays a major role in cellular antioxidant defence, results from recent studies have highlighted its ubiquitous roles in cellular cytoprotection including anti-inflammatory function. As oxidative stress and inflammatory tissue damage are two major culprits in the pathogenesis of the majority of malignancies and other disorders, Nrf2 is recognized as a potential preventive target. Some chemoprotective and chemopreventive phytochemicals are capable of activating Nrf2 signaling, thereby fortifying cellular defence capacity.
ISSN
1021-9498
URI
https://hdl.handle.net/10371/172786
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Graduate School of Convergence Science and Technology (융합과학기술대학원)Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과)Journal Papers (저널논문_분자의학 및 바이오제약학과)
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