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cis-9,trans-11-Conjugated linoleic acid down-regulates phorbol ester-induced NF-κB activation and subsequent COX-2 expression in hairless mouse skin by targeting IκB kinase and PI3K-Akt : cis-9,trans-11-Conjugated linoleic acid down-regulates phorbol ester-induced NF-kappa B activation and subsequent COX-2 expression in hairless mouse skin by targeting I kappa B kinase and PI3K-Akt
DC Field | Value | Language |
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dc.contributor.author | Hwang, Dal-Mi | - |
dc.contributor.author | Kundu, Joydeb Kumar | - |
dc.contributor.author | Shin, Jun-Wan | - |
dc.contributor.author | Lee, Jung-Chul | - |
dc.contributor.author | Lee, Hyong Joo | - |
dc.contributor.author | Surh, Young-Joon | - |
dc.date.accessioned | 2021-01-31T10:18:02Z | - |
dc.date.available | 2021-01-31T10:18:02Z | - |
dc.date.created | 2017-11-15 | - |
dc.date.issued | 2007-02 | - |
dc.identifier.citation | Carcinogenesis, Vol.28 No.2, pp.363-371 | - |
dc.identifier.issn | 0143-3334 | - |
dc.identifier.other | 3529 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172801 | - |
dc.description.abstract | Conjugated linoleic acid (CLA) has been reported to inhibit mouse skin carcinogenesis, particularly in the promotion stage, but underlying molecular mechanisms remain poorly understood. Since persistent induction of cyclooxygenase-2 (COX-2) is frequently implicated in carcinogenesis, we investigated the effect of cis-9,trans-11-CLA (9Z,11E-CLA) on the tumor promoter-induced COX-2 expression in HR-1 hairless mouse skin in vivo. Topical application of 9Z,11E-CLA caused significant inhibition of COX-2 expression at 6 h induced by 10 nmol 12-O-tetradecanoylphorbol-13-acetate (TPA) in HR-1 mouse skin. Since NF-kappa B is known to regulate COX-2 gene expression, we determined the effect of 9Z,11E-CLA on TPA-induced activation of this transcription factor. Treatment of mouse skin with 9Z,11E-CLA reduced TPA-induced DNA binding as well as nuclear translocation of NF-kappa B by blocking phosphorylation and subsequent degradation of I kappa B alpha. In addition, 9Z,11E-CLA attenuated TPA-induced phosphorylation of extracellular signal-regulated protein kinase, p38 mitogen-activated protein kinase and Akt. To further elucidate the molecular mechanism underlying the inactivation of NF-kappa B by 9Z,11E-CLA, we investigated its effect on TPA-induced activation of I kappa B kinase (IKK), an upstream kinase that regulates NF-kappa B via phosphorylation and degradation of I kappa B alpha. 9Z,11E-CLA treatment down-regulated phosphorylation and catalytic activities of IKK alpha/beta in TPA-treated mouse skin. Co-treatment of mouse skin with the IKK beta-specific inhibitor SC-514 (1 mu mol) attenuated TPA-induced activation of Akt and NF-kappa B, and also the expression of COX-2 in hairless mouse skin. Taken together, 9Z,11E-CLA inhibits NF-kappa B driven-COX-2 expression by blocking the IKK and PI3K-Akt signaling in TPA-treated hairless mouse skin in vivo, which may account for its previously reported anti-tumor promoting effects. | - |
dc.language | 영어 | - |
dc.publisher | Oxford University Press | - |
dc.title | cis-9,trans-11-Conjugated linoleic acid down-regulates phorbol ester-induced NF-κB activation and subsequent COX-2 expression in hairless mouse skin by targeting IκB kinase and PI3K-Akt | - |
dc.title.alternative | cis-9,trans-11-Conjugated linoleic acid down-regulates phorbol ester-induced NF-kappa B activation and subsequent COX-2 expression in hairless mouse skin by targeting I kappa B kinase and PI3K-Akt | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.identifier.doi | 10.1093/carcin/bgl151 | - |
dc.citation.journaltitle | Carcinogenesis | - |
dc.identifier.wosid | 000244124800015 | - |
dc.identifier.scopusid | 2-s2.0-33847277462 | - |
dc.citation.endpage | 371 | - |
dc.citation.number | 2 | - |
dc.citation.startpage | 363 | - |
dc.citation.volume | 28 | - |
dc.identifier.sci | 000244124800015 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Lee, Hyong Joo | - |
dc.contributor.affiliatedAuthor | Surh, Young-Joon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | INFLAMMATION-ASSOCIATED CANCER | - |
dc.subject.keywordPlus | SIGNAL-TRANSDUCTION PATHWAYS | - |
dc.subject.keywordPlus | MAMMARY EPITHELIAL-CELLS | - |
dc.subject.keywordPlus | ANTIINFLAMMATORY PHYTOCHEMICALS | - |
dc.subject.keywordPlus | TRANSACTIVATION DOMAIN | - |
dc.subject.keywordPlus | MOLECULAR-MECHANISMS | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | P65 SUBUNIT | - |
dc.subject.keywordPlus | CYCLOOXYGENASE-2 | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
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