Publications
Detailed Information
Enzymic reduction of [6]-gingerol, a major pungent principle of ginger, in the cell-free preparation of rat liver
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Surh, Young-Joon | - |
dc.contributor.author | Lee, Sang Sup | - |
dc.date.accessioned | 2021-01-31T10:18:57Z | - |
dc.date.available | 2021-01-31T10:18:57Z | - |
dc.date.created | 2017-11-15 | - |
dc.date.issued | 1994 | - |
dc.identifier.citation | Life Sciences, Vol.54 No.19, pp.PL321-PL326 | - |
dc.identifier.issn | 0024-3205 | - |
dc.identifier.other | 5574 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172817 | - |
dc.description.abstract | A reductive metabolism of S-(+)-[6]-gingerol [1-(4'-hydroxy-3'-methoxyphenyl)-5-hydroxydecan-3-one], the major pungent principle of ginger, was investigated in vitro with phenobarbital-induced rat liver 10,000 x g supernatant containing the NADPH-generating system. The ethyl acetate-extractable products were isolated and two metabolites were identified as diastereomers of [6]-gingerdiol by gas chromatography/mass spectrometry. The ratio of two isomers formed in die above reaction was about 1:5, suggesting the stereospecific reduction of S-(+)-[6]-gingerol by carbonyl reductase activity present in the postmitochondrial supernatant fraction of rat liver. The enzymic reduction of S-(+)-[61-gingerol thus introduces the second asymmetric carbon center in the molecule with concomitant production of S, S- and R, S-isomers of [6]-gingerdiol in different proportions. This stereospecific reduction of [6]-gingerol may be relevant to the clinical use of the compound. | - |
dc.language | 영어 | - |
dc.publisher | Elsevier BV | - |
dc.title | Enzymic reduction of [6]-gingerol, a major pungent principle of ginger, in the cell-free preparation of rat liver | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.identifier.doi | 10.1016/0024-3205(94)00602-4 | - |
dc.citation.journaltitle | Life Sciences | - |
dc.identifier.wosid | A1994ND19800010 | - |
dc.identifier.scopusid | 2-s2.0-0028209704 | - |
dc.citation.endpage | PL326 | - |
dc.citation.number | 19 | - |
dc.citation.startpage | PL321 | - |
dc.citation.volume | 54 | - |
dc.identifier.sci | A1994ND19800010 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Surh, Young-Joon | - |
dc.contributor.affiliatedAuthor | Lee, Sang Sup | - |
dc.type.docType | Letter | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ZINGIBER-OFFICINALE | - |
dc.subject.keywordPlus | MESENTERIC VEINS | - |
dc.subject.keywordPlus | PROSTAGLANDIN | - |
dc.subject.keywordPlus | CONSTITUENTS | - |
dc.subject.keywordPlus | DERIVATIVES | - |
dc.subject.keywordPlus | CONTRACTION | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | SHOGAOL | - |
dc.subject.keywordAuthor | [6]-GINGEROL | - |
dc.subject.keywordAuthor | XENOBIOTIC KETONE | - |
dc.subject.keywordAuthor | STEREOSPECIFIC REDUCTION OF GINGEROL | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.