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Inhibitory effects of the ginsenoside Rg3 on phorbol ester-induced cyclooxygenase-2 expression, NF-κB activation and tumor promotion

Cited 154 time in Web of Science Cited 170 time in Scopus
Authors
Keum, Young-Sam; Han, Seong Su; Chun, Kyung-Soo; Park, Kwang-Kyun; Park, Jeong-Hill; Lee, Seung Ki; Surh, Young-Joon
Issue Date
2003-02
Citation
Mutation Research, Vol.523, pp.75-85
Keywords
anti-tumor promotionAP-1cyclooxygenase-2ginsengginsenoside Rg(3)HL-60 cellsmouse skin carcinogenesisNF-kappa B
Abstract
Our previous studies demonstrated the anti-oxidant and anti-tumor promotional properties of the methanol extract of heat-processed Panax ginseng C.A. Meyer [Cancer Lett. 150 (2000) 41]. In the present work, we have evaluated anti-inflammatory as well as anti-tumor promoting effects of Rg(3), a major ginsenoside derived from heat-processed ginseng. Pretreatment of dorsal skins of female ICR mice with Rg(3) significantly inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ornithine decarboxylase activity and 7,12-dimethylbenz[a] anthracene-initiated papilloma formation. In another experiment, Rg(3) pretreatment abrogated the expression of cyclooxygenase-2 in TPA-stimulated mouse skin. Rg(3) also inhibited the TPA-induced activation of the eukaryotic transcription factor, NF-kappaB in both mouse skin and cultured human pro-myelocytic leukemia (HL-60) cells. Moreover, Rg(3) exerted potent inhibitory effects on the activation of another transcription factor, activator protein-1 (AP-1) that is responsible for c-jun and c-fos oncogenic transactivation. Based on these findings, it is likely that the anti-tumor promoting activity of Rg(3) is mediated possibly through down-regulation of NF-kappaB and AP-1 transcription factors. (C) 2002 Elsevier Science B.V. All rights reserved.
ISSN
0027-5107
URI
https://hdl.handle.net/10371/172836
DOI
https://doi.org/10.1016/S0027-5107(02)00323-8
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Graduate School of Convergence Science and Technology (융합과학기술대학원)Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과)Journal Papers (저널논문_분자의학 및 바이오제약학과)
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