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Inhibition of cyclooxygenase-2 expression and restoration of gap junction intercellular communication in H-ras-transformed rat liver epithelial cells by caffeic acid phenethyl ester
DC Field | Value | Language |
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dc.contributor.author | Lee, Ki Won | - |
dc.contributor.author | Chun, Kyung Soo | - |
dc.contributor.author | Lee, Jeong-Sang | - |
dc.contributor.author | Kang, Kyung Sun | - |
dc.contributor.author | Surh, Young-Joon | - |
dc.contributor.author | Lee, Hyong Joo | - |
dc.date.accessioned | 2021-01-31T10:20:35Z | - |
dc.date.available | 2021-01-31T10:20:35Z | - |
dc.date.created | 2017-11-15 | - |
dc.date.issued | 2004 | - |
dc.identifier.citation | Annals of the New York Academy of Sciences, Vol.1030, pp.501-507 | - |
dc.identifier.issn | 0077-8923 | - |
dc.identifier.other | 4307 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172843 | - |
dc.description.abstract | One of the most frequent defects in human cancers is the uncontrolled activation of the ras signaling pathways. Increased expression of cyclooxygenase-2 (COX-2) and inhibition of gap junction intercellular communication (GJIC) have been frequently observed in several forms of human malignancies. The present study investigated the effects of caffeic acid phenethyl ester (CAPE), a chemopreventive phytochemical derived from honey propolis, on COX-2 expression and GJIC in Harvey-ras-transformed WB-F344 rat liver epithelial cells (H-ras WB cells). H-ras induced COX-2 expression in WB-F344 rat liver epithelial cells (WB cells). H-ras WB cells also exhibited complete inhibition of GJIC and predominant unphosphorylation of connexin 43 (Cx43), a major protein modulating GJIC. CAPE significantly inhibited the constitutive expression of COX-2 and restored the disrupted GJIC through the phosphorylation of Cx43 at a concentration of 12.5 mu M in H-ras WB cells. Although the molecular basis for the cancer chemopreventive activity of CAPE is not completely understood, several studies suggest that CAPE is a potent and specific inhibitor of the transcription factor nuclear factor B-K (NF-B-K) activation. We also found that CAPE significantly inhibited H-ras-induced NF-B-K DNA-binding activity without affecting the activation of extracellular signal-regulated kinase and p38 mitogen-activated protein kinase, which are major intracellular molecules involved in the Ras signaling pathways. In conclusion, CAPE may exert cancer chemopreventive effects through the inhibition of COX-2 expression and the restoration of disrupted GJIC induced by H-ras, possibly by targeting NF-B-K. | - |
dc.language | 영어 | - |
dc.publisher | New York Academy of Sciences | - |
dc.title | Inhibition of cyclooxygenase-2 expression and restoration of gap junction intercellular communication in H-ras-transformed rat liver epithelial cells by caffeic acid phenethyl ester | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.identifier.doi | 10.1196/annals.1329.062 | - |
dc.citation.journaltitle | Annals of the New York Academy of Sciences | - |
dc.identifier.wosid | 000228128100061 | - |
dc.identifier.scopusid | 2-s2.0-15044342684 | - |
dc.citation.endpage | 507 | - |
dc.citation.startpage | 501 | - |
dc.citation.volume | 1030 | - |
dc.identifier.sci | 000228128100061 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Lee, Ki Won | - |
dc.contributor.affiliatedAuthor | Kang, Kyung Sun | - |
dc.contributor.affiliatedAuthor | Surh, Young-Joon | - |
dc.contributor.affiliatedAuthor | Lee, Hyong Joo | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | PHYTOCHEMICALS | - |
dc.subject.keywordPlus | SUPPRESSION | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordAuthor | H-ras | - |
dc.subject.keywordAuthor | cyclooxygenase-2 | - |
dc.subject.keywordAuthor | gap junction intercellular communication | - |
dc.subject.keywordAuthor | nuclear factor kappa B | - |
dc.subject.keywordAuthor | caffeic acid phenethyl ester | - |
dc.subject.keywordAuthor | rat liver epithelial cells | - |
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