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Inhibition of cyclooxygenase-2 expression and restoration of gap junction intercellular communication in H-ras-transformed rat liver epithelial cells by caffeic acid phenethyl ester

DC Field Value Language
dc.contributor.authorLee, Ki Won-
dc.contributor.authorChun, Kyung Soo-
dc.contributor.authorLee, Jeong-Sang-
dc.contributor.authorKang, Kyung Sun-
dc.contributor.authorSurh, Young-Joon-
dc.contributor.authorLee, Hyong Joo-
dc.date.accessioned2021-01-31T10:20:35Z-
dc.date.available2021-01-31T10:20:35Z-
dc.date.created2017-11-15-
dc.date.issued2004-
dc.identifier.citationAnnals of the New York Academy of Sciences, Vol.1030, pp.501-507-
dc.identifier.issn0077-8923-
dc.identifier.other4307-
dc.identifier.urihttps://hdl.handle.net/10371/172843-
dc.description.abstractOne of the most frequent defects in human cancers is the uncontrolled activation of the ras signaling pathways. Increased expression of cyclooxygenase-2 (COX-2) and inhibition of gap junction intercellular communication (GJIC) have been frequently observed in several forms of human malignancies. The present study investigated the effects of caffeic acid phenethyl ester (CAPE), a chemopreventive phytochemical derived from honey propolis, on COX-2 expression and GJIC in Harvey-ras-transformed WB-F344 rat liver epithelial cells (H-ras WB cells). H-ras induced COX-2 expression in WB-F344 rat liver epithelial cells (WB cells). H-ras WB cells also exhibited complete inhibition of GJIC and predominant unphosphorylation of connexin 43 (Cx43), a major protein modulating GJIC. CAPE significantly inhibited the constitutive expression of COX-2 and restored the disrupted GJIC through the phosphorylation of Cx43 at a concentration of 12.5 mu M in H-ras WB cells. Although the molecular basis for the cancer chemopreventive activity of CAPE is not completely understood, several studies suggest that CAPE is a potent and specific inhibitor of the transcription factor nuclear factor B-K (NF-B-K) activation. We also found that CAPE significantly inhibited H-ras-induced NF-B-K DNA-binding activity without affecting the activation of extracellular signal-regulated kinase and p38 mitogen-activated protein kinase, which are major intracellular molecules involved in the Ras signaling pathways. In conclusion, CAPE may exert cancer chemopreventive effects through the inhibition of COX-2 expression and the restoration of disrupted GJIC induced by H-ras, possibly by targeting NF-B-K.-
dc.language영어-
dc.publisherNew York Academy of Sciences-
dc.titleInhibition of cyclooxygenase-2 expression and restoration of gap junction intercellular communication in H-ras-transformed rat liver epithelial cells by caffeic acid phenethyl ester-
dc.typeArticle-
dc.contributor.AlternativeAuthor서영준-
dc.identifier.doi10.1196/annals.1329.062-
dc.citation.journaltitleAnnals of the New York Academy of Sciences-
dc.identifier.wosid000228128100061-
dc.identifier.scopusid2-s2.0-15044342684-
dc.citation.endpage507-
dc.citation.startpage501-
dc.citation.volume1030-
dc.identifier.sci000228128100061-
dc.description.isOpenAccessN-
dc.contributor.affiliatedAuthorLee, Ki Won-
dc.contributor.affiliatedAuthorKang, Kyung Sun-
dc.contributor.affiliatedAuthorSurh, Young-Joon-
dc.contributor.affiliatedAuthorLee, Hyong Joo-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.subject.keywordPlusNF-KAPPA-B-
dc.subject.keywordPlusACTIVATION-
dc.subject.keywordPlusPHYTOCHEMICALS-
dc.subject.keywordPlusSUPPRESSION-
dc.subject.keywordPlusMECHANISMS-
dc.subject.keywordPlusAPOPTOSIS-
dc.subject.keywordPlusINDUCTION-
dc.subject.keywordPlusCANCER-
dc.subject.keywordAuthorH-ras-
dc.subject.keywordAuthorcyclooxygenase-2-
dc.subject.keywordAuthorgap junction intercellular communication-
dc.subject.keywordAuthornuclear factor kappa B-
dc.subject.keywordAuthorcaffeic acid phenethyl ester-
dc.subject.keywordAuthorrat liver epithelial cells-
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