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Protective effects of green tea polyphenol extracts against ethanol-induced gastric mucosal damages in rats: Stress-responsive transcription factors and MAP kinases as potential targets

Cited 45 time in Web of Science Cited 48 time in Scopus
Authors
Lee, Jeong-Sang; Oh, Tae-Young; Kim, Young-Kyung; Baik, Joo-Hyun; So, Sung; Hahm, Ki-Baik; Surh, Young-Joon
Issue Date
2005-11
Citation
Mutation Research, Vol.579 No.1-2, pp.214-224
Keywords
green tea polyphenolethanol-induced gastropathyCOX-2 and iNOStranscription factorsmitogen-activated protein kinases
Abstract
There are multiple lines of compelling evidence from epidemiologic and laboratory studies supporting that frequent consumption of green tea is inversely associated with the risk of chronic human diseases including cancer. The chemopreventive and chemoprotective effects of green tea have been largely attributed to antioxidative and anti-inflammatory activities of its polyphenolic constituents, such as epigallocatechin gallate. The present study was designed to evaluate the efficacy of green tea polyphenols in protecting against alcohol-induced gastric damage and to elucidate the underlying mechanisms. Intragastric administration of ethanol to male Sprague-Dawley rats caused significant gastric mucosal damage, which was accompanied by elevated expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (NOS) its well as transient activation of redox-sensitive transcription factors, such as NF-kappa B and AP-1, and mitogen-activated protein kinases (MAPKs). Oral administration of the green tea polyphenolic extract (GTE) significantly ameliorated mucosal damages induced by ethanol and also attenuated the ethanol-induced expression of COX-2 and NOS. Inactivation of MAPKs, especially p38 and ERK1/2, by GTE might be responsible for inhibition of ethanol-induced expression of COX-2 and NOS. (c) 2005 Elsevier B.V. All rights reserved.
ISSN
0027-5107
URI
https://hdl.handle.net/10371/172846
DOI
https://doi.org/10.1016/j.mrfmmm.2005.03.027
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Graduate School of Convergence Science and Technology (융합과학기술대학원)Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과)Journal Papers (저널논문_분자의학 및 바이오제약학과)
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