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Inhibitory effects of isopropyl-2-(1,3-dithietane-2-ylidene)-2-[N-(4-methylthiazol-2-yl)carbam oyl]acetate (YH439) on benzo[a]pyrene-induced skin carcinogenesis and micronucleated reticulocyte formation in mice
DC Field | Value | Language |
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dc.contributor.author | Surh, Young-Joon | - |
dc.contributor.author | Kim, Seong Gon | - |
dc.contributor.author | Liem, Amy | - |
dc.contributor.author | Lee, Jong Wook | - |
dc.contributor.author | Miller, James A | - |
dc.date.accessioned | 2021-01-31T10:21:34Z | - |
dc.date.available | 2021-01-31T10:21:34Z | - |
dc.date.created | 2017-11-15 | - |
dc.date.issued | 1999-01 | - |
dc.identifier.citation | Mutation Research, Vol.423 No.1-2, pp.149-153 | - |
dc.identifier.issn | 0027-5107 | - |
dc.identifier.other | 5178 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172859 | - |
dc.description.abstract | Recently, a great deal of attention has been devoted to organosulfur compounds with potential cancer chemopreventive properties. Many sulfur-containing substances present in Brassica plants have been reported to possess striking anticarcinogenic and antimutagenic activities. Besides naturally occurring organosulfur compounds, certain synthetic sulfur-containing pharmaceuticals, such as oltipraz and sulindac, are known to exert substantial chemopreventive or chemoprotective effects. Isopropyl-2-(1,3-dithietane-2-ylidene)-2-[N-(4-methylthiazol-2-yl)carbamoyl]acetate (YH439) was initially developed for its possible use as a hepatoprotectant. The compound has been found to up-regulate the expression of cytochrome P-450 IA1 [I.J. Lee, K.S. Jeong, B.J. Roberts, A.T. Kallarakal, P. Fernandez-Salguero, F.J. Gonzalez, B.J. Song, Transcriptional induction of the cytochrome P-450 1A1 gene by a thiazolium compound YH439, Mel. Pharmacol. 49 (1996) 980-988.] which plays a pivotal role in metabolism of the majority of polycyclic aromatic carcinogens and mutagens, such as benzo[a]pyrene (B[a]P). In the present study, we found that oral administration of YH439 to CD-1 mice significantly suppressed B[a]P-initiated skin tumorigenesis. B[a]P-induced formation of micronuclei in mouse peripheral reticulocytes was also attenuated by YH439 pretreatment. Likewise, diallyl sulfide, a major volatile thioether present in garlic, also protected against B[a]P-induced skin tumorigenesis and micronucleated reticulocyte formation in mice. (C) 1999 Elsevier Science B.V. All rights reserved. | - |
dc.language | 영어 | - |
dc.publisher | Elsevier BV | - |
dc.title | Inhibitory effects of isopropyl-2-(1,3-dithietane-2-ylidene)-2-[N-(4-methylthiazol-2-yl)carbam oyl]acetate (YH439) on benzo[a]pyrene-induced skin carcinogenesis and micronucleated reticulocyte formation in mice | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.identifier.doi | 10.1016/S0027-5107(98)00236-X | - |
dc.citation.journaltitle | Mutation Research | - |
dc.identifier.wosid | 000078569300018 | - |
dc.identifier.scopusid | 2-s2.0-0033601850 | - |
dc.citation.endpage | 153 | - |
dc.citation.number | 1-2 | - |
dc.citation.startpage | 149 | - |
dc.citation.volume | 423 | - |
dc.identifier.sci | 000078569300018 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Surh, Young-Joon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | RAT HEPATOCYTES | - |
dc.subject.keywordPlus | CHEMOPREVENTION | - |
dc.subject.keywordPlus | OLTIPRAZ | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | GLUTATHIONE | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | HEPATOTOXICITY | - |
dc.subject.keywordPlus | PROTECTION | - |
dc.subject.keywordPlus | COMPOUND | - |
dc.subject.keywordPlus | AGENT | - |
dc.subject.keywordAuthor | chemoprevention | - |
dc.subject.keywordAuthor | organosulfur compound | - |
dc.subject.keywordAuthor | isopropyl-2-(1,3-dithietane-2-ylidene)-2-[N-(4-methyl-2-thiazol-2-yl)car bamoyl]acetate (YH439) | - |
dc.subject.keywordAuthor | diallyl sulfide | - |
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