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β-Amyloid induces oxidative DNA damage and cell death through activation of c-Jun N terminal kinase

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dc.contributor.authorJang, Jung-Hee-
dc.contributor.authorSurh, Young-Joon-
dc.date.accessioned2021-01-31T10:22:49Z-
dc.date.available2021-01-31T10:22:49Z-
dc.date.issued2002-
dc.identifier.citationAnnals of the New York Academy of Sciences, Vol.973, pp.228-236-
dc.identifier.issn0077-8923-
dc.identifier.other4741-
dc.identifier.urihttps://hdl.handle.net/10371/172879-
dc.description.abstractOxidative stress induced by reactive oxygen species has been implicated in the pathophysiology of many neurodegenerative disorders including Alzheimer's disease (AD). In this study, we have investigated the molecular mechanisms underlying oxidative cell death induced by beta-amyloid, a neurotoxic peptide associated with senile plaques found in the brains of patients with AD. PC12 cells treated with P-amyloid underwent apoptotic cell death as determined by characteristic morphological features, cleavage of poly(ADPribose)polymerase, and positive in situ terminal-end labeling (TUNEL). Furthermore, beta-amyloid treatment led to activation of c-Jun N terminal kinase (JNK) and intracellular accumulation of ROS. In another experiment, beta-amyloid caused strand scission in phiX174 DNA in the presence of ferrous iron. These findings suggest that production of ROS and subsequent activation of JNK play an important role in beta-amyloid-induced apoptotic cell death.-
dc.subjectbeta-amyloid-
dc.subjectoxidative stress-
dc.subjectDNA damage-
dc.subjectapoptosis-
dc.subjectc-Jun N terminal kinase-
dc.titleβ-Amyloid induces oxidative DNA damage and cell death through activation of c-Jun N terminal kinase-
dc.typeArticle-
dc.contributor.AlternativeAuthor서영준-
dc.identifier.doi10.1111/j.1749-6632.2002.tb04639.x-
dc.citation.journaltitleAnnals of the New York Academy of Sciences-
dc.identifier.scopusid2-s2.0-0036959437-
dc.citation.endpage236-
dc.citation.startpage228-
dc.citation.volume973-
dc.identifier.urlhttps://nyaspubs.onlinelibrary.wiley.com/doi/full/10.1111/j.1749-6632.2002.tb04639.x-
dc.identifier.rimsid4741-
dc.identifier.sci000179853000045-
dc.contributor.affiliatedAuthorSurh, Young-Joon-
Appears in Collections:
Graduate School of Convergence Science and Technology (융합과학기술대학원)Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과)Journal Papers (저널논문_분자의학 및 바이오제약학과)
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