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Induction of cyclooxygenase-2 in ras-transformed human mammary epithelial cells undergoing apoptosis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Na, Hye-Kyung | - |
dc.contributor.author | Surh, Young-Joon | - |
dc.date.accessioned | 2021-01-31T10:22:55Z | - |
dc.date.available | 2021-01-31T10:22:55Z | - |
dc.date.created | 2017-11-15 | - |
dc.date.issued | 2002 | - |
dc.identifier.citation | Annals of the New York Academy of Sciences, Vol.973, pp.153-160 | - |
dc.identifier.issn | 0077-8923 | - |
dc.identifier.other | 4740 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172880 | - |
dc.description.abstract | COX-2 expression has been reported to be elevated in several forms of human cancer. The presence of oncogenic ras has been associated with constitutive induction of COX-2, which confers resistance to apoptosis. Contrary to the above notion, we have found that H-ras-transformed human breast epithelial (MCF10A-ras) cells treated with the anticancer drug ET-18-0-CH3 exhibit an increased expression of COX-2, while they still undergo apoptosis. To determine whether the induction of COX-2 by ET-18-0-CH3 could contribute to apoptosis in MCF10A-ras cells, the selective COX-2 inhibitor celecoxib (SC-58635) was used. Celecoxib treatment attenuated ET-18-0-CH3-induced cell death. Taken together, the above findings suggest that COX-2 up-regulation does not necessarily confer the resistance to apoptosis in ras-transformed cells, but rather may sensitize these cells to apoptotic death. | - |
dc.language | 영어 | - |
dc.publisher | New York Academy of Sciences | - |
dc.title | Induction of cyclooxygenase-2 in ras-transformed human mammary epithelial cells undergoing apoptosis | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.identifier.doi | 10.1111/j.1749-6632.2002.tb04626.x | - |
dc.citation.journaltitle | Annals of the New York Academy of Sciences | - |
dc.identifier.wosid | 000179853000032 | - |
dc.identifier.scopusid | 2-s2.0-0036959459 | - |
dc.citation.endpage | 160 | - |
dc.citation.startpage | 153 | - |
dc.citation.volume | 973 | - |
dc.identifier.sci | 000179853000032 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Surh, Young-Joon | - |
dc.type.docType | Article; Proceedings Paper | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | FAMILIAL ADENOMATOUS POLYPOSIS | - |
dc.subject.keywordPlus | CANCER CELLS | - |
dc.subject.keywordPlus | PHORBOL ESTER | - |
dc.subject.keywordPlus | COLON-CANCER | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | COX-2 | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordPlus | KINASE | - |
dc.subject.keywordPlus | OVEREXPRESSION | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordAuthor | celecoxib | - |
dc.subject.keywordAuthor | cyclooxygenase-2 (COX-2) | - |
dc.subject.keywordAuthor | ET-18-O-CH3 | - |
dc.subject.keywordAuthor | human breast epithelial cells | - |
dc.subject.keywordAuthor | ras-transformed cells | - |
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