Browse

Bioactivation of Cyclopenta- and Cyclohexa-fused Polycyclic Aromatic Hydrocarbons via the Formation of Benzylic Sulfuric Acid Esters

DC Field Value Language
dc.contributor.authorSurh, Young-Joon-
dc.contributor.authorTannenbaum, Steven R.-
dc.date.accessioned2021-01-31T10:23:44Z-
dc.date.available2021-01-31T10:23:44Z-
dc.date.issued1994-
dc.identifier.citationPolycyclic Aromatic Compounds, Vol.7 No.1-3, pp.83-90-
dc.identifier.issn1040-6638-
dc.identifier.other85300-
dc.identifier.urihttps://hdl.handle.net/10371/172892-
dc.description.abstractThere has been accumulated evidence that sulfo-conjugation plays an important role in the formation of electrophilic, mutagenic, and tumorigenic sulfuric acid ester metabolites from some hydroxymethyl aromatic hydrocarbons. In the present study, we have investigated whether sulfotransferases can also activate cyclopenta- and cyclohexa-fused polycyclic aromatic hydrocarbons containing secondary benzylic hydroxyl group(s). Thus, 3,4-dihydroxy-3,4-dihydrocyclopenta[cd]pyrene, as well as its monohydroxy analogs, covalently bound to DNA when incubated with rat liver cytosol and the sulfo-group donor, 3-phosphoadenosine-5-phosphosulfate. Likewise, 7-hydroxy-7,8,9,10-tetrahydrobcnzo[a]pyrene was activated to form an electrophilic and mutagenic species through sulfuric acid esterification. However, neither benzo[a]pyrene-7,8-dihydrodiol nor 7,8,9,10-tetrahydroxy-7,8,9,10-tetrahydrobenzo[a]pyrene produced reactive species in the presence of sulfotransferase activity. © 1994, Taylor & Francis Group, LLC. All rights reserved.-
dc.subjectbenzylic sulfate esters-
dc.subjectcyclopenta-fused PAH-
dc.subjectmetabolic activation-
dc.subjectmutagenicity-
dc.subjectsulfate conjugation-
dc.subjectsulfotransferases-
dc.titleBioactivation of Cyclopenta- and Cyclohexa-fused Polycyclic Aromatic Hydrocarbons via the Formation of Benzylic Sulfuric Acid Esters-
dc.typeArticle-
dc.contributor.AlternativeAuthor서영준-
dc.identifier.doi10.1080/10406639408014716-
dc.citation.journaltitlePolycyclic Aromatic Compounds-
dc.identifier.scopusid2-s2.0-0010631749-
dc.citation.endpage90-
dc.citation.number1-3-
dc.citation.startpage83-
dc.citation.volume7-
dc.identifier.urlhttps://www.tandfonline.com/doi/abs/10.1080/10406639408014716-
dc.identifier.rimsid85300-
dc.contributor.affiliatedAuthorSurh, Young-Joon-
Appears in Collections:
Graduate School of Convergence Science and Technology (융합과학기술대학원)Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과)Journal Papers (저널논문_분자의학 및 바이오제약학과)
Files in This Item:
There are no files associated with this item.
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse